Staniforth D H
Beecham Clinical Pharmacology Unit, West Middlesex University Hospital, Isleworth, UK.
Eur J Clin Pharmacol. 1987;33(1):55-8. doi: 10.1007/BF00610380.
The comparative actions of two benzamides; the one metoclopramide, having and the other, BRL 20627, lacking dopamine receptor antagonist properties have been investigated on orocaecal transit time (OCTT) using the lactulose/breath hydrogen method. In addition, the action of codeine, propantheline and domperidone on OCTT has been assessed. Similar quantitative reductions in apparent OCTT were found with metoclopramide and BRL 20627 thus, metoclopramide 20 mg orally and 10 mg i.v. brought about 32.5% and 42% reductions in OCTT. Similar reductions were also found using 20 mg BRL 20627 orally and 10 mg i.v. (31 and 26% respectively). In addition 20 mg domperidone orally was found to cause a 10% reduction. Codeine orally and propantheline i.m. brought about increases in the assessed transit time.
已使用乳果糖/呼气氢方法，对两种苯甲酰胺（一种是具有多巴胺受体拮抗剂特性的甲氧氯普胺，另一种是缺乏该特性的BRL 20627）对口盲肠转运时间（OCTT）的比较作用进行了研究。此外，还评估了可待因、丙胺太林和多潘立酮对OCTT的作用。甲氧氯普胺和BRL 20627均使表观OCTT出现类似程度的缩短，因此，口服20 mg和静脉注射10 mg甲氧氯普胺分别使OCTT缩短32.5%和42%。口服20 mg和静脉注射10 mg BRL 20627也出现类似程度的缩短（分别为31%和26%）。此外，发现口服20 mg多潘立酮可使OCTT缩短10%。口服可待因和肌肉注射丙胺太林使评估的转运时间延长。
