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新型丙型肝炎病毒核心+1/ARF蛋白在基于JFH1的复制子背景下的表达

Expression of the novel hepatitis C virus core+1/ARF protein in the context of JFH1-based replicons.

作者信息

Kotta-Loizou Ioly, Karakasiliotis Ioannis, Vassilaki Niki, Sakellariou Panagiotis, Bartenschlager Ralf, Mavromara Penelope

机构信息

Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece.

Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany.

出版信息

J Virol. 2015 May;89(9):5164-70. doi: 10.1128/JVI.02351-14. Epub 2015 Feb 18.

DOI:10.1128/JVI.02351-14
PMID:25694591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4403472/
Abstract

Hepatitis C virus contains a second open reading frame within the core gene, designated core+1/ARF. Here we demonstrate for the first time expression of core+1/ARF protein in the context of a bicistronic JFH1-based replicon and report the production of two isoforms, core+1/L (long) and core+1/S (short), with different kinetics.

摘要

丙型肝炎病毒在核心基因内含有第二个开放阅读框，命名为core+1/ARF。在此，我们首次证明了core+1/ARF蛋白在基于JFH1的双顺反子复制子环境中的表达，并报告了两种具有不同动力学的异构体core+1/L（长型）和core+1/S（短型）的产生。

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本文引用的文献

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New expensive treatments for hepatitis C infection.丙型肝炎感染的新型昂贵治疗方法。
JAMA. 2014 Aug 13;312(6):593-4. doi: 10.1001/jama.2014.8897.
2
Hepatitis C virus core+1/ARF protein decreases hepcidin transcription through an AP1 binding site.丙型肝炎病毒核心+1/ARF 蛋白通过一个 AP1 结合位点降低铁调素转录。
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Optimization of transfection methods for Huh-7 and Vero cells: comparative study.Huh-7和Vero细胞转染方法的优化：比较研究
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New insights into structure and replication of the hepatitis C virus and clinical implications.丙型肝炎病毒结构与复制的新认识及其临床意义。
Semin Liver Dis. 2010 Nov;30(4):333-47. doi: 10.1055/s-0030-1267535. Epub 2010 Oct 19.
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Internal translation initiation stimulates expression of the ARF/core+1 open reading frame of HCV genotype 1b.内部翻译起始刺激 HCV 基因型 1b 的 ARF/core+1 开放阅读框的表达。
Virus Res. 2011 Jan;155(1):213-20. doi: 10.1016/j.virusres.2010.10.007. Epub 2010 Oct 17.
6
Role of the hepatitis C virus core+1 open reading frame and core cis-acting RNA elements in viral RNA translation and replication.丙型肝炎病毒核心+1开放阅读框及核心顺式作用RNA元件在病毒RNA翻译与复制中的作用
J Virol. 2008 Dec;82(23):11503-15. doi: 10.1128/JVI.01640-08. Epub 2008 Sep 17.
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Differential reactivity of putative genotype 2 hepatitis C virus F protein between chronic and recovered infections.慢性感染和康复感染之间假定的2型丙型肝炎病毒F蛋白的差异反应性。
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