新型丙型肝炎病毒核心+1/ARF蛋白在基于JFH1的复制子背景下的表达
Expression of the novel hepatitis C virus core+1/ARF protein in the context of JFH1-based replicons.
作者信息
Kotta-Loizou Ioly, Karakasiliotis Ioannis, Vassilaki Niki, Sakellariou Panagiotis, Bartenschlager Ralf, Mavromara Penelope
机构信息
Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece.
Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany.
出版信息
J Virol. 2015 May;89(9):5164-70. doi: 10.1128/JVI.02351-14. Epub 2015 Feb 18.
Abstract
Hepatitis C virus contains a second open reading frame within the core gene, designated core+1/ARF. Here we demonstrate for the first time expression of core+1/ARF protein in the context of a bicistronic JFH1-based replicon and report the production of two isoforms, core+1/L (long) and core+1/S (short), with different kinetics.
摘要
丙型肝炎病毒在核心基因内含有第二个开放阅读框，命名为core+1/ARF。在此，我们首次证明了core+1/ARF蛋白在基于JFH1的双顺反子复制子环境中的表达，并报告了两种具有不同动力学的异构体core+1/L（长型）和core+1/S（短型）的产生。
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