Fatemi Naeini Farahnaz, Abtahi-Naeini Bahareh, Sadeghiyan Hamidreza, Nilforoushzadeh Mohammad Ali, Najafian Jamshid, Pourazizi Mohsen
Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran ; Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
J Skin Cancer. 2015;2015:306543. doi: 10.1155/2015/306543. Epub 2015 Jan 28.
Background. Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. Extensive studies on Iranian MF patients are absent. The present study aimed to produce updated clinical information on Iranian MF patients. Methods. This was a retrospective, descriptive, single-center study, including all cases of MF seen in the Department of Dermatology, University Hospital of Isfahan, Iran, between 2003 and 2013. Data systematically recorded for each patient included clinical, biological, histological, and molecular findings. Results. Eighty-six patients with clinical and histologic diagnosis of MF were included in the study. Thirty-nine patients (45.3%) were male. Female predominance was observed in patients (male : female ratio is 1 : 1.2). Patients were between 7 and 84 years of age (median: 41). The interval from disease onset to diagnosis ranged from 0 to 55 years (median: 1 year). Eighteen cases (20.9%) had unusual variants of MF. The most common types included hypopigmented and poikilodermatous MF. Childhood cases of MF constituted 5.8% (5/86) of all patients. The early stages were seen in 82 cases (95.34%). Conclusion. The major differences in epidemiologic characteristics of MF in Iran are the lack of male predominance and the lower age of patients at the time of diagnosis.
背景。蕈样肉芽肿（MF）是皮肤T细胞淋巴瘤最常见的亚型。目前尚无针对伊朗MF患者的广泛研究。本研究旨在提供有关伊朗MF患者的最新临床信息。方法。这是一项回顾性、描述性、单中心研究，纳入了2003年至2013年间在伊朗伊斯法罕大学医院皮肤科就诊的所有MF病例。系统记录的每位患者的数据包括临床、生物学、组织学和分子学检查结果。结果。86例临床和组织学诊断为MF的患者纳入研究。39例（45.3%）为男性。观察到女性占优势（男∶女比例为1∶1.2）。患者年龄在7至84岁之间（中位数：41岁）。从疾病发作到诊断的时间间隔为0至55年（中位数：1年）。18例（20.9%）有MF的不常见变异型。最常见的类型包括色素减退性和皮肤异色病样MF。儿童期MF病例占所有患者的5.8%（5/86）。82例（95.34%）处于疾病早期。结论。伊朗MF患者流行病学特征的主要差异在于缺乏男性优势以及诊断时患者年龄较低。
