Farvin K H Sabeena, Anandan R, Kumar S Hari Senthil, Shiny K S, Mathew Suseela, Sankar T V, Nair P G Viswanathan
Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), Cochin, India.
J Med Food. 2006 Winter;9(4):531-6. doi: 10.1089/jmf.2006.9.531.
We studied the cardioprotective effect of squalene on isoprenaline-induced myocardial infarction in male albino rats with respect to changes in the levels of lipid components in plasma and heart tissue. Prior administration of 2% squalene in feed for 45 days significantly reduced the isoprenaline-induced elevation in the levels of cholesterol, triglycerides, and free fatty acids in plasma and heart tissue of rats following myocardial infarction. It exerted an antilipidemic effect by reducing the level of low-density lipoprotein cholesterol with a parallel rise in the level of high-density lipoprotein cholesterol in plasma of experimental rats. A tendency to prevent the isoprenaline-induced depletion of phospholipids in the myocardium of experimental rats was also observed. In the present study, the pretreatment with squalene significantly counteracted the isoprenaline-induced lipid peroxidation and maintained the rats at near normal status. The results of the present study indicate that the overall cardioprotective effect of squalene is probably related to an inhibition of lipid accumulation by its hypolipidemic properties and/or its antioxidant properties.
我们研究了角鲨烯对异丙肾上腺素诱导的雄性白化大鼠心肌梗死的心脏保护作用，以及血浆和心脏组织中脂质成分水平的变化。在饲料中预先给予2%角鲨烯45天，可显著降低异丙肾上腺素诱导的心肌梗死后大鼠血浆和心脏组织中胆固醇、甘油三酯和游离脂肪酸水平的升高。它通过降低实验大鼠血浆中低密度脂蛋白胆固醇水平，同时升高高密度脂蛋白胆固醇水平，发挥抗血脂作用。还观察到角鲨烯有预防异丙肾上腺素诱导的实验大鼠心肌中磷脂消耗的趋势。在本研究中，角鲨烯预处理显著对抗了异丙肾上腺素诱导的脂质过氧化，并使大鼠维持在接近正常的状态。本研究结果表明，角鲨烯的总体心脏保护作用可能与其降血脂特性和/或抗氧化特性对脂质积累的抑制作用有关。
