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灵长类动物结核病检测的非侵入性试验。

Noninvasive test for tuberculosis detection among primates.

作者信息

Wolf Tiffany M, Mugisha Lawrence, Shoyama Fernanda Miyagaki, O'Malley Melanie J, Flynn JoAnne L, Asiimwe Benon, Travis Dominic A, Singer Randall S, Sreevatsan Srinand

出版信息

Emerg Infect Dis. 2015 Mar;21(3):468-70. doi: 10.3201/eid2103.140052.

Abstract

Traditional testing methods have limited epidemiologic studies of tuberculosis among free-living primates. PCR amplification of insertion element IS6110 of Mycobacterium tuberculosis from fecal samples was evaluated as a noninvasive screening test for tuberculosis in primates. Active tuberculosis was detected among inoculated macaques and naturally exposed chimpanzees, demonstrating the utility of this test.

摘要

传统检测方法限制了对自由生活灵长类动物结核病的流行病学研究。对粪便样本中结核分枝杆菌插入元件IS6110进行PCR扩增,被评估为灵长类动物结核病的一种非侵入性筛查检测方法。在接种的猕猴和自然暴露的黑猩猩中检测到活动性结核病,证明了该检测方法的实用性。

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本文引用的文献

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