Maliehe Maphori, Ntoi Mathope A, Lahiri Shayanki, Folorunso Olufemi S, Ogundeji Adepemi O, Pohl Carolina H, Sebolai Olihile M
Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, Bloemfontein 9301, Free State, South Africa.
Microorganisms. 2020 Jan 28;8(2):180. doi: 10.3390/microorganisms8020180.
The ability of microorganisms to colonise and display an intracellular lifestyle within a host body increases their fitness to survive and avoid extinction. This host-pathogen association drives microbial evolution, as such organisms are under selective pressure and can become more pathogenic. Some of these microorganisms can quickly spread through the environment via transmission. The non-transmittable fungal pathogens, such as probably return into the environment upon decomposition of the infected host. This review analyses whether re-entry of the pathogen into the environment causes restoration of its non-pathogenic state or whether environmental factors and parameters assist them in maintaining pathogenesis. is therefore used as a model organism to evaluate the impact of environmental stress factors that aid the survival and pathogenesis of intracellularly and extracellularly.
微生物在宿主体内定殖并呈现细胞内生活方式的能力增强了它们的生存适应性并避免灭绝。这种宿主 - 病原体关联推动了微生物进化,因为此类生物体处于选择压力之下,可能会变得更具致病性。其中一些微生物可通过传播在环境中迅速扩散。不可传播的真菌病原体,例如,可能在受感染宿主分解后返回环境。本综述分析病原体重新进入环境是否会导致其非致病状态的恢复,或者环境因素和参数是否有助于它们维持致病性。因此,被用作模式生物来评估有助于其在细胞内和细胞外生存及致病的环境应激因素的影响。