Bello Natalie A, Arany Zoltan
Division of Cardiology, Columbia University Medical Center, New York, NY.
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Trends Cardiovasc Med. 2015 Aug;25(6):499-504. doi: 10.1016/j.tcm.2015.01.004. Epub 2015 Jan 15.
Peripartum cardiomyopathy (PPCM) is characterized by the development of systolic heart failure in the last month of pregnancy or within the first 5 months postpartum. The disease affects between 1:300 and 1:3000 births worldwide. Heart failure can resolve spontaneously but often does not. Mortality rates, like incidence, vary widely based on location, ranging from 0% to 25%. The consequences of PPCM are thus often devastating for an otherwise healthy young woman and her newborn. The cause of PPCM remains elusive. Numerous hypotheses have been proposed, with mixed supporting evidence. Recent work has suggested that PPCM is a vascular disease, triggered by the profound hormonal changes of late gestation. We focus here on these new mechanistic findings, and their potential implication for understanding and treating PPCM.
围产期心肌病（PPCM）的特征是在妊娠最后一个月或产后前5个月内出现收缩性心力衰竭。全球范围内，该病在每300至3000例分娩中出现1例。心力衰竭可能会自发缓解，但通常不会。死亡率与发病率一样，因地区而异，范围从0%到25%。因此，PPCM的后果对于原本健康的年轻女性及其新生儿来说往往是毁灭性的。PPCM的病因仍然不明。已经提出了许多假说，支持证据不一。最近的研究表明，PPCM是一种血管疾病，由妊娠晚期深刻的激素变化引发。我们在此关注这些新的机制发现及其对理解和治疗PPCM的潜在意义。
