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微泡的稳定化与制备:在医学用途和功能材料方面的应用

Stabilization and fabrication of microbubbles: applications for medical purposes and functional materials.

作者信息

Lee Mina, Lee Eun Yeol, Lee Daeyeon, Park Bum Jun

机构信息

Department of Chemical Engineering, Kyung Hee University, Yongin, 446-701, South Korea.

出版信息

Soft Matter. 2015 Mar 21;11(11):2067-79. doi: 10.1039/c5sm00113g.

DOI:10.1039/c5sm00113g
PMID:25698443
Abstract

Microbubbles with diameters ranging from a few micrometers to tens of micrometers have garnered significant attention in various applications including food processing, water treatment, enhanced oil recovery, surface cleaning, medical purposes, and material preparation fields with versatile functionalities. A variety of techniques have been developed to prepare microbubbles, such as ultrasonication, excimer laser ablation, high shear emulsification, membrane emulsification, an inkjet printing method, electrohydrodynamic atomization, template layer-by-layer deposition, and microfluidics. Generated bubbles should be immediately stabilized via the adsorption of stabilizing materials (e.g., surfactants, lipids, proteins, and solid particles) onto the gas-liquid interface to lower the interfacial tension. Such adsorption of stabilizers prevents coalescence between the microbubbles and also suppresses gas dissolution and resulting disproportionation caused by the presence of the Laplace overpressure across the gas-liquid interface. Herein, we comprehensively review three important topics of microbubbles: stabilization, fabrication, and applications.

摘要

直径从几微米到几十微米不等的微泡在包括食品加工、水处理、强化采油、表面清洁、医学用途以及具有多种功能的材料制备领域等各种应用中受到了广泛关注。已经开发了多种制备微泡的技术,如超声处理、准分子激光烧蚀、高剪切乳化、膜乳化、喷墨打印法、电液动力雾化、模板逐层沉积和微流体技术。产生的气泡应通过将稳定材料(如表面活性剂、脂质、蛋白质和固体颗粒)吸附到气液界面上,以立即稳定下来,从而降低界面张力。这种稳定剂的吸附可防止微泡之间的聚并,还可抑制气体溶解以及由气液界面上的拉普拉斯超压导致的气体歧化。在此,我们全面综述微泡的三个重要主题:稳定性、制备方法和应用。

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