使用傅里叶域光学相干断层扫描对健康人群小梁网进行体内形态测量。

Morphometry of the trabecular meshwork in vivo in a healthy population using fourier-domain optical coherence tomography.

作者信息

Fernández-Vigo José I, García-Feijóo Julián, Martínez-de-la-Casa Jose M, García-Bella Javier, Fernández-Vigo José A

机构信息

Clínico San Carlos University Hospital, Department of Ophthalmology, Institute of Health Research, Complutense University of Madrid, Madrid, Spain International Center of Advanced Ophthalmology, Madrid, Spain.

Clínico San Carlos University Hospital, Department of Ophthalmology, Institute of Health Research, Complutense University of Madrid, Madrid, Spain.

出版信息

Invest Ophthalmol Vis Sci. 2015 Feb 19;56(3):1782-8. doi: 10.1167/iovs.14-16154.

DOI:10.1167/iovs.14-16154

PMID:25698706

Abstract

PURPOSE

We measured the length, thickness, and area of the trabecular meshwork (TM) in vivo using Fourier domain optical coherence tomography (FD-OCT) in a Caucasian population of healthy subjects.

METHODS

A cross-sectional study was done of 1006 healthy subjects. Left eyes were randomly selected. Age, sex, IOP, and spherical refractive error were noted. The depth and volume of the anterior chamber and the central corneal thickness were measured with Pentacam, while IOL Master was used to measure the axial length. The length, thickness, and area of the TM were measured through FD-OCT RTVue. A study was done to determine the correlation between TM size, and other demographic and ocular parameters. Finally, the reproducibility of the measurements was assessed for a subgroup of 50 eyes from 50 patients.

RESULTS

We were able to measure the TM in 91.1% of the total eyes studied. The mean TM length was 496.99 ± 92.77 μm (range, 275-800), TM thickness was 174.16 ± 28.14 μm (range, 100-276), and TM area was 0.069 ± 0.031 mm(2) (range, 0.023-0.133). No differences were found in terms of length and area for sex, although the TM was slightly thicker in men (P = 0.046). No correlation was observed between the TM measurements and any of the studied demographic or ocular parameters (R < 0.09, P < 0.001). Intra- and interobserver reproducibility of the measurements were good (intraclass correlation coefficient > 0.750, P < 0.001).

CONCLUSIONS

The FD-OCT is an effective and reproducible examination technique to measure the length, thickness, and area of the TM in vivo.

摘要

目的

我们使用傅里叶域光学相干断层扫描（FD-OCT）在白种健康受试者群体中对小梁网（TM）的长度、厚度和面积进行了活体测量。

方法

对1006名健康受试者进行了一项横断面研究。随机选择左眼。记录年龄、性别、眼压和球镜屈光不正。使用Pentacam测量前房深度和容积以及中央角膜厚度，同时使用IOL Master测量眼轴长度。通过FD-OCT RTVue测量TM的长度、厚度和面积。开展一项研究以确定TM大小与其他人口统计学和眼部参数之间的相关性。最后，对来自50名患者的50只眼的亚组进行测量的可重复性评估。

结果

在所研究的全部眼中，我们能够测量TM的比例为91.1%。TM的平均长度为496.99±92.77μm（范围275 - 800），TM厚度为174.16±28.14μm（范围100 - 276），TM面积为0.069±0.031mm²（范围0.023 - 0.133）。性别在长度和面积方面无差异，尽管男性的TM略厚（P = 0.046）。未观察到TM测量值与任何所研究的人口统计学或眼部参数之间存在相关性（R < 0.09，P < 0.001）。测量的观察者内和观察者间可重复性良好（组内相关系数> 0.750，P < 0.001）。