ELTE-MTA "Lendulet" Biophysics Research Group, Department of Biological Physics, Eötvös University, Pázmány Peter Setany 1A, H-1117 Budapest, Hungary.
Phys Rev Lett. 2015 Feb 6;114(5):058101. doi: 10.1103/PhysRevLett.114.058101. Epub 2015 Feb 3.
Biological macromolecules experience two seemingly very different types of noise acting on different time scales: (i) point mutations corresponding to changes in molecular sequence and (ii) thermal fluctuations. Examining the secondary structures of a large number of microRNA precursor sequences and model lattice proteins, we show that the effects of single point mutations are statistically indistinguishable from those of an increase in temperature by a few tens of kelvins. The existence of such an effective mutational temperature establishes a quantitative connection between robustness to genetic (mutational) and environmental (thermal) perturbations.
生物大分子经历两种似乎非常不同类型的噪声，作用于不同的时间尺度：（i）点突变对应于分子序列的变化，以及（ii）热波动。通过检查大量 microRNA 前体序列和模型晶格蛋白质的二级结构，我们表明，单点突变的影响在统计学上与温度升高几十开尔文的影响无法区分。这种有效突变温度的存在在遗传（突变）和环境（热）扰动的稳健性之间建立了定量联系。
