Yassin Sanaa A, Al-Tamimi Elham R, Al-Hassan Sultan
Department of Ophthalmology, University of Dammam, Dammam, Saudi Arabia.
King Fahd Hospital-University, PO Box 40097, Al-Khobar, 31952, Saudi Arabia.
Int Ophthalmol. 2015 Dec;35(6):833-42. doi: 10.1007/s10792-015-0055-9. Epub 2015 Feb 21.
The aim of this study was to investigate the presence of increased macular or retinal nerve fiber layer thickness (RNFLT) in amblyopic eyes, find if the increased macular or RNFLT is related to the lack of response in amblyopic eyes, and to explore whether the increased central macular thickness (CMT) in amblyopic eyes is purely related to the hyperopia. This is a prospective descriptive study. CMT and peripapillary RNFLT were measured by spectral-domain optical coherence tomography to evaluate 60 patients with unilateral-treated amblyopia (median age 11.00 year). Patients were divided into two groups: 33 patients in recovered amblyopia group and 27 patients in persistent amblyopia group. The mean CMT in the recovered group was 247.31 (±23.4) versus 246.8 (±32.7) µm (p = 0.95) for the persistent group. The mean peripapillary RNFLT was 99.13 (±12.1) versus 99.9 (±14.9) µm (p = 0.85) for the persistent group. In anisometropic amblyopia, there was no significant difference in CMT and RNFLT in either group. Also there was no relation between the type of refractive error and CMT or RNFLT. There was no significant difference in CMT and RNFLT in amblyopic eyes for both the recovered amblyopia group and the persistent amblyopia group to explain the lack of response in persistent amblyopic eyes. Additionally there was no relation between the type of refractive error and CMT or peripapillary RNFLT.
本研究的目的是调查弱视眼中黄斑或视网膜神经纤维层厚度（RNFLT）是否增加，确定黄斑或RNFLT增加是否与弱视眼治疗无反应有关，并探讨弱视眼中中央黄斑厚度（CMT）增加是否仅与远视有关。这是一项前瞻性描述性研究。通过光谱域光学相干断层扫描测量CMT和视乳头周围RNFLT，以评估60例单侧治疗的弱视患者（中位年龄11.00岁）。患者分为两组：33例弱视恢复组患者和27例弱视持续组患者。恢复组的平均CMT为247.31（±23.4）μm，而持续组为246.8（±32.7）μm（p = 0.95）。持续组的平均视乳头周围RNFLT为99.13（±12.1）μm，而持续组为99.9（±14.9）μm（p = 0.85）。在屈光参差性弱视中，两组的CMT和RNFLT均无显著差异。屈光不正类型与CMT或RNFLT之间也无关联。弱视恢复组和弱视持续组的弱视眼中CMT和RNFLT均无显著差异，无法解释弱视持续组治疗无反应的原因。此外，屈光不正类型与CMT或视乳头周围RNFLT之间也无关联。
