Zalewski Bartłomiej M, Chmielewska Anna, Szajewska Hania
Department of Pediatrics, The Medical University of Warsaw, Warsaw, Poland.
Department of Pediatrics, The Medical University of Warsaw, Warsaw, Poland.
Nutrition. 2015 Mar;31(3):437-42.e2. doi: 10.1016/j.nut.2014.09.004. Epub 2014 Nov 25.
Glucomannan (GM), a soluble fiber derived from the plant Amorphophallus konjac, is marketed as being helpful in reducing body weight. However, the data supporting this claim are scarce. The aim of this review was to systematically evaluate the effects of GM on body weight (BW) and body mass index (BMI) in otherwise healthy obese or overweight children and adults.
MEDLINE, EMBASE, CENTRAL, and Google Scholar databases were systematically searched up to June 2014 for randomized controlled trials (RCTs) assessing the effectiveness of GM versus placebo. The primary outcome measures were BW and BMI.
Six eligible RCTs, only one of which performed in children, were included. In adults, three RCTs reported a significant reduction in BW in the GM group compared with the control group at the following different points during the intervention: At week 2 (mean difference [MD], 0.21 kg; 95% confidence interval [CI], 0.13-0.29); at week 4 (MD, 2.04; 95% CI, 0.52-3.56); at week 5 (MD, 1.3; 95% CI, 0.89-1.71); and at week 8 (MD, 3.17; 95% CI, 1.29-5.05). Only one RCT reported a beneficial effect at more than one point. None of the RCTs reported a favorable effect of GM on BMI.
In otherwise healthy overweight or obese adults, there is some evidence that in the short term GM may help to reduce BW, but not BMI. Data in children are too limited to draw any conclusions.
葡甘露聚糖（GM）是从魔芋植物中提取的一种可溶性纤维，其宣称有助于减轻体重。然而，支持这一说法的数据却很稀少。本综述的目的是系统评价GM对健康的肥胖或超重儿童及成人的体重（BW）和体重指数（BMI）的影响。
截至2014年6月，系统检索MEDLINE、EMBASE、CENTRAL和谷歌学术数据库，查找评估GM与安慰剂效果对比的随机对照试验（RCT）。主要结局指标为BW和BMI。
纳入了6项符合条件的RCT，其中只有1项是针对儿童进行的。在成人中，3项RCT报告称，与对照组相比，GM组在干预期间的以下不同时间点体重显著降低：第2周（平均差值[MD]，0.21 kg；95%置信区间[CI]，0.13 - 0.29）；第4周（MD，2.04；95% CI，0.52 - 3.56）；第5周（MD，1.3；95% CI，0.89 - 1.71）；第8周（MD，3.17；95% CI，1.29 - 5.05）。只有1项RCT报告在多个时间点有有益效果。没有RCT报告GM对BMI有有利影响。
在健康的超重或肥胖成人中，有一些证据表明短期内GM可能有助于减轻体重，但对BMI无作用。儿童的数据过于有限，无法得出任何结论。
