Karp Christopher L, Wilson Christopher B, Stuart Lynda M
Discovery and Translational Sciences, Global Health, The Bill & Melinda Gates Foundation, Seattle, WA, USA.
Immunol Rev. 2015 Mar;264(1):363-81. doi: 10.1111/imr.12270.
The road to a more efficacious vaccine that could be a truly transformative tool for decreasing tuberculosis morbidity and mortality, along with Mycobacterium tuberculosis transmission, is quite daunting. Despite this, there are reasons for optimism. Abetted by better conceptual clarity, clear acknowledgment of the degree of our current immunobiological ignorance, the availability of powerful new tools for dissecting the immunopathogenesis of human tuberculosis, the generation of more creative diversity in tuberculosis vaccine concepts, the development of better fit-for-purpose animal models, and the potential of more pragmatic approaches to the clinical testing of vaccine candidates, the field has promise for delivering novel tools for dealing with this worldwide scourge of poverty.
研发一种更有效的疫苗之路充满挑战,这种疫苗有望成为降低结核病发病率和死亡率以及结核分枝杆菌传播的真正变革性工具。尽管如此,仍有乐观的理由。在更清晰的概念、对当前免疫生物学无知程度的明确认识、剖析人类结核病免疫发病机制的强大新工具的可用性、结核病疫苗概念中产生的更具创造性的多样性、更适合目标的动物模型的开发以及对候选疫苗进行更务实的临床试验方法的潜力的推动下,该领域有望提供应对这一全球贫困祸害的新工具。