Hashemi Hayaa F, Goodman Joel M
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, United States.
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, United States.
Curr Opin Cell Biol. 2015 Apr;33:119-24. doi: 10.1016/j.ceb.2015.02.002. Epub 2015 Feb 20.
Proteomic studies have revealed many potential functions of cytoplasmic lipid droplets, and recent activity has confirmed that these bona fide organelles are central not only for lipid storage and metabolism, but for development, immunity, and pathogenesis by several microbes. There has been a burst of recent activity on the assembly, maintenance and turnover of lipid droplets that reveals fresh insights. This review summarizes several novel findings in initiation of lipid droplet assembly, protein targeting, droplet fusion, and turnover of droplets through lipophagy.
蛋白质组学研究揭示了细胞质脂滴的许多潜在功能,最近的研究活动证实,这些名副其实的细胞器不仅在脂质储存和代谢方面起着核心作用,而且在发育、免疫以及几种微生物的致病机制中也发挥着重要作用。最近关于脂滴的组装、维持和更新有大量研究活动,揭示了新的见解。本综述总结了脂滴组装起始、蛋白质靶向、脂滴融合以及通过脂质自噬进行脂滴更新方面的几个新发现。