脂滴的生物发生。
Lipid droplet biogenesis.
机构信息
Yale School of Medicine, Department of Cell Biology, New Haven, CT, USA.
Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California-San Francisco, CA, USA.
出版信息
Curr Opin Cell Biol. 2014 Aug;29:39-45. doi: 10.1016/j.ceb.2014.03.008. Epub 2014 Apr 14.
Abstract
Lipid droplets (LDs) are found in most cells, where they play central roles in energy and membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly understood process involving the formation of a monolayer bound organelle from a bilayer membrane. Additionally, large LDs can form either by growth of existing LDs or by the combination of smaller LDs through several distinct mechanisms. Here, we review recent insights into the molecular process governing LD biogenesis and highlight areas of incomplete knowledge.
摘要
脂滴（LDs）存在于大多数细胞中，在能量和膜脂代谢中发挥核心作用。LD 的从头生物发生是一个令人着迷但知之甚少的过程，涉及从双层膜形成单层结合细胞器。此外，大的 LD 可以通过现有 LD 的生长或通过几种不同的机制通过较小的 LD 的组合形成。在这里，我们回顾了最近对控制 LD 生物发生的分子过程的深入了解，并强调了知识不完善的领域。
相似文献
1
Lipid droplet biogenesis.脂滴的生物发生。
Curr Opin Cell Biol. 2014 Aug;29:39-45. doi: 10.1016/j.ceb.2014.03.008. Epub 2014 Apr 14.
2
Lipid droplet-organelle interactions: emerging roles in lipid metabolism.脂滴-细胞器相互作用：在脂质代谢中的新作用。
Curr Opin Cell Biol. 2015 Aug;35:91-7. doi: 10.1016/j.ceb.2015.04.017. Epub 2015 May 15.
3
Lipid droplet biogenesis: A mystery "unmixing"?脂滴生物发生：一场神秘的“解聚”？
Semin Cell Dev Biol. 2020 Dec;108:14-23. doi: 10.1016/j.semcdb.2020.03.001. Epub 2020 Mar 17.
4
Lipid Droplet and Peroxisome Biogenesis: Do They Go Hand-in-Hand?脂滴与过氧化物酶体生物发生：它们是携手并进的吗？
Front Cell Dev Biol. 2019 May 31;7:92. doi: 10.3389/fcell.2019.00092. eCollection 2019.
5
Lipid Droplet Biogenesis.脂滴生物发生。
Annu Rev Cell Dev Biol. 2017 Oct 6;33:491-510. doi: 10.1146/annurev-cellbio-100616-060608. Epub 2017 Aug 9.
6
Lipid droplet-organelle interactions; sharing the fats.脂滴与细胞器的相互作用；脂肪的共享
Biochim Biophys Acta. 2009 Jun;1791(6):441-7. doi: 10.1016/j.bbalip.2008.07.004. Epub 2008 Jul 30.
7
The role of caveolin-1 in lipid droplets and their biogenesis.窖蛋白-1在脂滴及其生物发生中的作用。
Chem Phys Lipids. 2018 Mar;211:93-99. doi: 10.1016/j.chemphyslip.2017.11.010. Epub 2017 Nov 21.
8
Imaging lipid droplet fusion and growth.成像脂滴融合与生长。
Methods Cell Biol. 2013;116:253-68. doi: 10.1016/B978-0-12-408051-5.00013-9.
9
A different kind of love - lipid droplet contact sites.别样的爱——脂滴接触位点。
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1188-1196. doi: 10.1016/j.bbalip.2017.06.005. Epub 2017 Jun 13.
10
Keeping FIT, storing fat: Lipid droplet biogenesis.保持健康，储存脂肪：脂滴生物合成。
Worm. 2016 Apr 4;5(2):e1170276. doi: 10.1080/21624054.2016.1170276. eCollection 2016 Apr-Jun.
引用本文的文献
1
Ring canals in the larval adipose of buffer stress response.幼虫脂肪体中的环管对应激反应的缓冲作用。 （原英文表述似乎不太完整准确，此译文是根据大致意思进行的完善翻译）
bioRxiv. 2025 Jun 11:2025.06.11.658881. doi: 10.1101/2025.06.11.658881.
2
Optical imaging of metabolic dynamics in ALS under methionine regulation.蛋氨酸调节下肌萎缩侧索硬化症代谢动力学的光学成像
J Biomed Opt. 2025 Feb;30(Suppl 2):S23906. doi: 10.1117/1.JBO.30.S2.S23906. Epub 2025 May 24.
3
The TOR Signaling Pathway Governs Fungal Development, Virulence and Ustiloxin Biosynthesis in .TOR信号通路调控真菌发育、毒力及玉蜀黍赤霉烯酮生物合成。
J Fungi (Basel). 2025 Mar 21;11(4):239. doi: 10.3390/jof11040239.
4
Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases.中枢神经系统中的脂滴以及各种疾病中含有脂滴的脑细胞的功能概况。
J Neuroinflammation. 2025 Jan 13;22(1):7. doi: 10.1186/s12974-025-03334-5.
5
The interaction networks of small rubber particle proteins in the latex of reveal diverse functions in stress responses and secondary metabolism.[橡胶树]胶乳中小橡胶粒子蛋白的相互作用网络在应激反应和次生代谢中显示出多种功能。 （注：原文中“of”后面缺少具体内容，这里补充了“橡胶树”使句子更完整，可根据实际情况调整）
Front Plant Sci. 2024 Dec 13;15:1498737. doi: 10.3389/fpls.2024.1498737. eCollection 2024.
6
Human platelet lysate enhances small lipid droplet accumulation of human MSCs through MAPK phosphorylation.人血小板裂解液通过丝裂原活化蛋白激酶磷酸化增强人间充质干细胞小脂滴的积累。
Stem Cell Res Ther. 2024 Dec 18;15(1):473. doi: 10.1186/s13287-024-04085-5.
7
Radiosensitizing capacity of fenofibrate in glioblastoma cells depends on lipid metabolism.非诺贝特在胶质母细胞瘤细胞中的放射增敏能力取决于脂质代谢。
Redox Biol. 2025 Feb;79:103452. doi: 10.1016/j.redox.2024.103452. Epub 2024 Dec 2.
8
Exploring the Dynamic Changes of Brain Lipids, Lipid Rafts, and Lipid Droplets in Aging and Alzheimer's Disease.探讨脑脂质、脂筏和脂滴在衰老和阿尔茨海默病中的动态变化。
Biomolecules. 2024 Oct 26;14(11):1362. doi: 10.3390/biom14111362.
9
The TOR signalling pathway in fungal phytopathogens: A target for plant disease control.真菌植物病原菌中的 TOR 信号通路：植物疾病防治的一个靶点。
Mol Plant Pathol. 2024 Nov;25(11):e70024. doi: 10.1111/mpp.70024.
10
Analysis of lipid uptake, storage, and fatty acid oxidation by group 2 innate lymphoid cells.分析 2 型固有淋巴细胞对脂质的摄取、储存和脂肪酸氧化作用。
Front Immunol. 2024 Oct 21;15:1493848. doi: 10.3389/fimmu.2024.1493848. eCollection 2024.
本文引用的文献
1
Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting.Arf1/衣被蛋白I机制直接作用于脂滴，并使其与内质网相连以进行蛋白质靶向运输。
Elife. 2014;3:e01607. doi: 10.7554/eLife.01607. Epub 2014 Feb 4.
2
Control of lipid droplet size in budding yeast requires the collaboration between Fld1 and Ldb16.在出芽酵母中，脂滴大小的控制需要Fld1和Ldb16之间的协作。
J Cell Sci. 2014 Mar 15;127(Pt 6):1214-28. doi: 10.1242/jcs.137737. Epub 2014 Jan 16.
3
Membranous appendices of spherosomes (oleosomes) : Possible role in fat utilization in germinating oil seeds.球形体（油体）的膜状附属物：在萌发的油籽中脂肪利用的可能作用。
Planta. 1978 Jan;140(2):163-9. doi: 10.1007/BF00384916.
4
Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains.酰基辅酶A合成酶3促进内质网微区室中脂滴的生物合成。
J Cell Biol. 2013 Dec 23;203(6):985-1001. doi: 10.1083/jcb.201305142.
5
Open questions in lipid droplet biology.脂滴生物学中的开放性问题。
Chem Biol. 2014 Jan 16;21(1):86-96. doi: 10.1016/j.chembiol.2013.08.009. Epub 2013 Nov 14.
6
The biophysics and cell biology of lipid droplets.脂滴的生物物理学和细胞生物学。
Nat Rev Mol Cell Biol. 2013 Dec;14(12):775-86. doi: 10.1038/nrm3699. Epub 2013 Nov 13.
7
Expression of oleosin and perilipins in yeast promotes formation of lipid droplets from the endoplasmic reticulum.油质蛋白和脂滴素在酵母中的表达促进了内质网中脂滴的形成。
J Cell Sci. 2013 Nov 15;126(Pt 22):5198-209. doi: 10.1242/jcs.131896. Epub 2013 Sep 4.
8
Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation.甘油-3-磷酸酰基转移酶（GPAT）-1，但不是 GPAT4，将新合成的脂肪酸掺入三酰基甘油中，并减少脂肪酸氧化。
J Biol Chem. 2013 Sep 20;288(38):27299-27306. doi: 10.1074/jbc.M113.485219. Epub 2013 Aug 1.
9
COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function.COPI 从重建的水-磷脂-三酰甘油界面上出芽 60nm 脂质滴，提示其具有张力夹功能。
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13244-9. doi: 10.1073/pnas.1307685110. Epub 2013 Jul 30.
10
A conserved role for atlastin GTPases in regulating lipid droplet size.网格蛋白相关鸟苷三磷酸酶在调节脂滴大小中的保守作用。
Cell Rep. 2013 May 30;3(5):1465-75. doi: 10.1016/j.celrep.2013.04.015. Epub 2013 May 16.
Zotero 插件