Xia Jiliang, Franqui Machin Reinaldo, Gu Zhimin, Zhan Fenghuang
Cancer Research Institute, Southern Medical University, Guangzhou, Guangdong 510515, China.
Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
Biomed Res Int. 2015;2015:862461. doi: 10.1155/2015/862461. Epub 2015 Feb 1.
Chromosome instability (CIN) has been identified as a common feature of most human cancers. A number of centrosomal kinases are thought to cause CIN in cancer cells. Part of those centrosomal kinases exhibit elevated expression in a wide variety of tumours and cancer cell lines. Additionally, critical roles in many aspects of cancer cell growth, proliferation, metastasis, and drug resistance have been assigned to some of these centrosomal kinases, such as polo-like kinase 1 (PLk1) and Aurora-A kinase. Recent studies from our group and others revealed that a centrosomal kinase, Never in Mitosis (NIMA) Related Kinase 2A (NEK2A), is frequently upregulated in multiple types of human cancers. Uncontrolled activity of NEK2A activates several oncogenic pathways and ABC transporters, thereby leading to CIN, cancer cell proliferation, metastasis, and enhanced drug resistance. In this paper, we highlight recent findings on the aberrant expression and functional significance of NEK2A in human cancers and emphasize their significance for therapeutic potentials.
染色体不稳定（CIN）已被确定为大多数人类癌症的一个共同特征。许多中心体激酶被认为会导致癌细胞中的CIN。这些中心体激酶中的一部分在多种肿瘤和癌细胞系中表现出表达升高。此外，这些中心体激酶中的一些，如polo样激酶1（PLk1）和Aurora-A激酶，在癌细胞生长、增殖、转移和耐药性的许多方面都发挥着关键作用。我们团队和其他团队最近的研究表明，一种中心体激酶，即有丝分裂中从未出现过（NIMA）相关激酶2A（NEK2A），在多种类型的人类癌症中经常上调。NEK2A的不受控制的活性激活了几种致癌途径和ABC转运蛋白，从而导致CIN、癌细胞增殖、转移和增强的耐药性。在本文中，我们重点介绍了关于NEK2A在人类癌症中的异常表达和功能意义的最新发现，并强调了它们对治疗潜力的重要性。
