Buchanan R, Hydes T, Khakoo S I
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Tissue Antigens. 2015 Apr;85(4):231-40. doi: 10.1111/tan.12540. Epub 2015 Feb 24.
Infection with hepatitis C virus (HCV) leads to a wide spectrum of clinical manifestations. This heterogeneity is underpinned by the host immune response and the genetic factors that govern it. Polymorphisms affecting both the innate and adaptive immunity determine the outcome of exposure. However the innate immune system appears to play a greater role in determining treatment-associated responses. Overall the effects of IFNL3/4 appear dominant over other polymorphic genes. Understanding how host genetics determines the disease phenotype has not been as intensively studied. This review summarizes our current understanding of innate and adaptive immunogenetic factors in the outcome of HCV infection. It focuses on how they relate to resolution and the progression of HCV-related liver disease, in the context of current and future treatment regimes.
丙型肝炎病毒（HCV）感染会导致广泛的临床表现。这种异质性由宿主免疫反应及其调控的遗传因素所支撑。影响先天免疫和适应性免疫的多态性决定了接触病毒后的结果。然而，先天免疫系统在决定治疗相关反应方面似乎发挥着更大的作用。总体而言，IFNL3/4的影响似乎比其他多态性基因更为显著。目前对宿主遗传学如何决定疾病表型的研究还不够深入。这篇综述总结了我们目前对HCV感染结果中先天和适应性免疫遗传因素的理解。它聚焦于在当前和未来治疗方案的背景下，这些因素如何与HCV相关肝病的缓解和进展相关联。
