O'Connor Kate S, George Jacob, Booth David, Ahlenstiel Golo
Kate S O'Connor, David Booth, Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, NSW 2145, Australia.
World J Gastroenterol. 2014 Dec 21;20(47):17830-8. doi: 10.3748/wjg.v20.i47.17830.
Recently, single nucleotide polymorphisms, in the vicinity of the interferon lambda 3 (IFNL3) gene have been identified as the strongest predictor of spontaneous and treatment induced clearance of hepatitis C virus (HCV) infection. Since then, increasing evidence has implicated the innate immune response in mediating the IFNL3 genotype effect. Dendritic cells (DCs) are key to the host immune response in HCV infection and their vital role in the IFNL3 genotype effect is emerging. Reports have identified subclasses of DCs, particularly myeloid DC2s and potentially plasmacytoid DCs as the major producers of IFNL3 in the setting of HCV infection. Given the complexities of dendritic cell biology and the conflicting current available data, this review aims to summarize what is currently known regarding the role of dendritic cells in HCV infection and to place it into context of what is know about lambda interferons and dendritic cells in general.
最近，在干扰素λ3（IFNL3）基因附近的单核苷酸多态性已被确定为丙型肝炎病毒（HCV）感染自发清除和治疗诱导清除的最强预测指标。从那时起，越来越多的证据表明先天免疫反应在介导IFNL3基因型效应中起作用。树突状细胞（DCs）是HCV感染中宿主免疫反应的关键，其在IFNL3基因型效应中的重要作用正在显现。报告已确定DCs的亚类，特别是髓样DC2s以及潜在的浆细胞样DCs是HCV感染情况下IFNL3的主要产生者。鉴于树突状细胞生物学的复杂性以及当前现有数据的矛盾性，本综述旨在总结目前已知的树突状细胞在HCV感染中的作用，并将其置于关于λ干扰素和一般树突状细胞的已知背景中。
