Curto Martina, Lionetto Luana, Fazio Francesco, Mitsikostas Dimos-Dimitrios, Martelletti Paolo
Psychiatric Unit, Neurosciences, Mental Health and Sensory Organs (NESMOS) Department, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Intern Emerg Med. 2015 Jun;10(4):413-21. doi: 10.1007/s11739-015-1208-6. Epub 2015 Feb 24.
Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to activate glutamate receptors, thus potentially influencing a large group of functions in the central nervous system (CNS). Migraine, a largely unknown pathology, is strictly related to the glutamate system in the CNS pathologic terms. Despite the large number of studies conducted on migraine etio-pathology, the kynurenine pathway has been only recently linked to this disease. Nonetheless, some evidence suggests an intriguing role for some kynurenines, and an exploratory study on the serum kynurenine level might be helpful to better understand possible alterations of the kynurenine pathway in patients suffering from migraine.
犬尿氨酸途径是色氨酸代谢在数量上的主要分支，长期以来一直被认为是烟酰胺腺嘌呤二核苷酸的一个来源，尽管其几种产物，即所谓的犬尿氨酸，具有激活谷氨酸受体的能力，从而可能影响中枢神经系统（CNS）中的一大类功能。偏头痛是一种很大程度上尚不明确的病症，在中枢神经系统病理学方面与谷氨酸系统密切相关。尽管针对偏头痛的病因病理学进行了大量研究，但犬尿氨酸途径直到最近才与这种疾病联系起来。然而，一些证据表明某些犬尿氨酸具有有趣的作用，对血清犬尿氨酸水平进行探索性研究可能有助于更好地了解偏头痛患者犬尿氨酸途径的可能改变。
