Beta-blockers with ACE inhibitors--a logical combination?

Although there is no obvious pharmacological rationale for the combined use of an ACE inhibitor and a beta-blocker in the treatment of hypertension, this combination has proved to be more effective than monotherapy in a number of studies, some of which are reviewed. Moreover, there is evidence that this combination may be beneficial after myocardial infarction. Combined use of ACE inhibitor and beta-blocker therapy therefore warrants further investigation.