Zhao Lei, Hao Xingan, Wu Yunfeng
College of Plant Protection, State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Crop Pest Integrated Pest Management on Crop in Northwestern Loess Plateau, Ministry of Agriculture, Northwest A&F University, Yangling, 712100, PR China; Key Laboratory of Plant Protection Resources and Pest Management, Ministry of Education, Northwest A&F University, Yangling, 712100, PR China.
College of Plant Protection, State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Crop Pest Integrated Pest Management on Crop in Northwestern Loess Plateau, Ministry of Agriculture, Northwest A&F University, Yangling, 712100, PR China; Key Laboratory of Plant Protection Resources and Pest Management, Ministry of Education, Northwest A&F University, Yangling, 712100, PR China.
Int J Biol Macromol. 2015 Apr;75:474-8. doi: 10.1016/j.ijbiomac.2015.01.058. Epub 2015 Feb 20.
Polysaccharides are essential macromolecules present in all living organisms, and have many kinds of biological activities, such as anti-oxidation, hypoglycemic, enhancing immunity, anti-aging, anti-rheumatism, anti-cancer and so on. In this study, the antiviral activity of polysaccharide peptide (PSP) was tested, compared with Ningnanmycin, and firstly found it has a stronger antiviral activity by using half-leaf method and leaf disk method. Subsequently, the mechanism of antiviral activity of PSP was preliminarily studied. As a result, its antiviral effect was better than the commercial agent Ningnanmycin, despite of protective effect, curative effect and inactivation effect. On the other hand, PSP as a commercial anti-cancer drug could easily and rapidly get in large quantities by liquid fermentation, which makes the industrialized production feasible. Also PSP is less toxic, easily biodegradable and ecofriendly. All the results are suggesting that PSP has potential as a pesticide to be used for the control of plant virus in the future.
多糖是所有生物体内存在的重要大分子，具有多种生物活性，如抗氧化、降血糖、增强免疫力、抗衰老、抗风湿、抗癌等。本研究对多糖肽（PSP）的抗病毒活性进行了测试，并与宁南霉素进行了比较，首次采用半叶法和叶盘法发现其具有较强的抗病毒活性。随后，对PSP抗病毒活性的机制进行了初步研究。结果表明，无论在保护作用、治疗作用还是灭活作用方面，其抗病毒效果均优于商业药剂宁南霉素。另一方面，PSP作为一种商业抗癌药物，通过液体发酵能够轻松快速地大量获得，这使得工业化生产成为可能。此外，PSP毒性较小，易于生物降解且环保。所有结果表明，PSP未来有潜力作为一种农药用于防治植物病毒。
