Ghajarzadeh Mahsa, Mohammadifar Mehdi, Azarkhish Kamran, Emami-Razavi Seyed Hassan
Department of Neurology, Brain and Spinal Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Radiology, Zanjan University of Medical Sciences, Zanjan, Iran.
Int J Prev Med. 2014 Dec;5(12):1521-8.
We did this systematic review to determine diagnostic accuracy of sono-elastography in evaluating cervical lymph nodes (LNs). A highly sensitive search for sono-elastography and LNs was performed in MEDLINE, Cochrane Library, ACP Journal Club, EMBASE, Health Technology assessment, and ISI web of knowledge for studies published prior to December 2012. SPSS version 18 (SPSS Inc., Chicago, IL, USA) used for descriptive analysis and meta-disk version 1.4 applied for meta-analysis. Forest plots for pooled estimates and summery of receiver operating characteristic plots for different cut-offs were produced. The literature and manual search yielded 69 articles, of which 10 were eligible to include. A total of 578 individuals with a total number of 936 cervical LNs was evaluated (502 malignant and 434 benign). The summary sensitivity of the scoring and strain ratio (SR) measurements for the differentiation of benign and malignant LNs were 0.76 (95% CI: 0.71-0.8) and 0.83 (95% CI: 0.78-0.87). The summary specificities were 0.8 (95% confidence interval [CI]: 0.75-0.84) and 0.84 (95% CI: 0.79-0.88), respectively. Area under the curve for scoring system was 0.86 (standard error [SE] = 0.03) and 0.95 (SE = 0.02) for SR measurement. Sono-elastograohy has high accuracy in differentiating benign and malignant cervical LNs.
我们进行了这项系统评价，以确定超声弹性成像在评估颈部淋巴结方面的诊断准确性。在MEDLINE、Cochrane图书馆、美国内科医师学会杂志俱乐部、EMBASE、卫生技术评估和ISI知识网中，对2012年12月之前发表的关于超声弹性成像和颈部淋巴结的研究进行了高度敏感的检索。使用SPSS 18版（美国伊利诺伊州芝加哥市SPSS公司）进行描述性分析，并应用Meta-Disk 1.4版进行荟萃分析。生成了合并估计的森林图和不同截断值的受试者操作特征图汇总。文献检索和手工检索共获得69篇文章，其中10篇符合纳入标准。共评估了578名个体的936个颈部淋巴结（502个为恶性，434个为良性）。用于区分良性和恶性淋巴结的评分和应变率（SR）测量的汇总敏感性分别为0.76（95%CI：0.71-0.8）和0.83（95%CI：0.78-0.87）。汇总特异性分别为0.8（95%置信区间[CI]：0.75-0.84）和0.84（95%CI：0.79-0.88）。评分系统的曲线下面积为0.86（标准误[SE]=0.03），SR测量的曲线下面积为0.95（SE=0.02）。超声弹性成像在区分良性和恶性颈部淋巴结方面具有较高的准确性。
