Sequeira Damien I, Ebert Lars C, Flach Patricia M, Ruder Thomas D, Thali Michael J, Ampanozi Garyfalia
MedStar Union Memorial Hospital, Georgetown University, 200 E. University Parkway, 33rd Street Professional Bldg. Suite 631, Baltimore, MD, 21218, USA.
Forensic Sci Med Pathol. 2015 Jun;11(2):186-92. doi: 10.1007/s12024-015-9659-7. Epub 2015 Feb 25.
The goal of this study was to assess whether epicardial and paracardial adipose tissue volumes, as determined by computed tomography (CT), correlate with coronary artery stenosis as determined by autopsy. The postmortem CT data and autopsy findings of 116 adult human decedents were retrospectively compared. Subjects were classified into three groups according to their degree of coronary artery stenosis: ≥50, <50%, and no stenosis. Epicardial and paracardial adipose tissue volumes were calculated based on manual segmentation after threshold based masking. In addition, epicardial adipose tissue thickness was measured using a caliper. All three parameters (thickness of epicardial fat and volumes of both epicardial and paracardial fat) were compared among the three groups and correlated with the degree of coronary artery stenosis. The group with no coronary artery stenosis showed the lowest mean values of epicardial adipose tissue volume, while the coronary artery stenosis ≥50 % group showed the highest volume. All measured variables (thickness of epicardial fat and volumes of both epicardial and paracardial fat) correlated significantly with the grade of coronary artery stenosis, even after controlling for BMI, however, epicardial adipose tissue volume exhibited the strongest correlation. This study reveals that there is an association between the degree of coronary artery stenosis and the amount of epicardial fat tissue: The larger the volume of epicardial fat, the higher the degree of coronary artery stenosis.
本研究的目的是评估通过计算机断层扫描（CT）测定的心外膜和心包旁脂肪组织体积是否与尸检确定的冠状动脉狭窄相关。对116例成年人类死者的死后CT数据和尸检结果进行了回顾性比较。根据冠状动脉狭窄程度将受试者分为三组：≥50%、<50%和无狭窄。在心阈值掩蔽后通过手动分割计算心外膜和心包旁脂肪组织体积。此外，使用卡尺测量心外膜脂肪组织厚度。比较三组之间的所有三个参数（心外膜脂肪厚度以及心外膜和心包旁脂肪的体积），并将其与冠状动脉狭窄程度相关联。无冠状动脉狭窄组的心外膜脂肪组织体积平均值最低，而冠状动脉狭窄≥50%组的体积最高。即使在控制体重指数后，所有测量变量（心外膜脂肪厚度以及心外膜和心包旁脂肪的体积）均与冠状动脉狭窄分级显著相关，然而，心外膜脂肪组织体积表现出最强的相关性。本研究表明，冠状动脉狭窄程度与心外膜脂肪组织量之间存在关联：心外膜脂肪体积越大，冠状动脉狭窄程度越高。
