用于多环四酰胺大环内酯官能化的混杂羟化酶——将伊卡鲁霉素转化为布特霉素。
Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams--conversion of ikarugamycin to butremycin.
作者信息
Greunke Christian, Antosch Janine, Gulder Tobias A M
机构信息
Biosystems Chemistry, Department of Chemistry and Center for Integrated Protein Science Munich (CIPSM), Technische Universität München, Lichtenbergstraße 4, 85747 Garching, Germany.
出版信息
Chem Commun (Camb). 2015 Mar 28;51(25):5334-6. doi: 10.1039/c5cc00843c.
Polycyclic tetramate macrolactams (PTMs) are a structurally, biomedically and biosynthetically intriguing class of bacterial metabolites. By combining parts of the machineries of different PTM biosynthetic pathways, we demonstrate for the first time the substrate promiscuity of a class of PTM tailoring enzymes, thereby facilitating the (bio)synthesis of butremycin.
多环四胺大环内酯（PTM）是一类在结构、生物医学和生物合成方面都很有趣的细菌代谢产物。通过整合不同PTM生物合成途径的部分机制，我们首次证明了一类PTM修饰酶的底物选择性，从而促进了布曲霉素的（生物）合成。
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