Ghafouri-Fard Soudeh, Gholami Leila, Nazer Naghme, Hussen Bashdar Mahmud, Sayad Arezou, Hajiesmaeili Mohammadreza
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Periodontics, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Front Mol Neurosci. 2022 Aug 24;15:950919. doi: 10.3389/fnmol.2022.950919. eCollection 2022.
Periodontitis is a common oral disorder leading to tooth loss in both developed and developing regions of the world. This multifactorial condition is related to the abnormal activity of several molecular pathways, among them are oxytocin-related pathways. In this study, we enrolled 26 patients and 28 controls and assessed the expression of four oxytocin-related genes, namely, , , , and , in circulation and affected tissues of enrolled individuals using real-time PCR. Expression of was downregulated in total periodontitis tissues compared with total control tissues [ratio of mean expression (RME) = 0.23, -value = 0.03]. Expression of was also lower in total blood samples of patients compared with total controls. Expression of was downregulated in total periodontitis tissues compared with total control tissues (RME = 0.16, -value = 0.01). Moreover, the expression of was reduced in total blood samples of patients compared with controls (RME = 0.25, -value = 0.03). Expression of was downregulated in total periodontitis tissues compared with total control tissues (RME = 0.17, -value = 0.01). However, the expression of was not different in blood samples of affected vs. unaffected individuals. Finally, the expression of was lower in total periodontitis tissues compared with total control tissues (RME = 0.24, -value = 0.01) and in total blood samples of affected individuals compared with controls (RME = 0.42, -value = 0.05). This study provides data about the association between expressions of oxytocin-related genes and the presence of periodontitis. Future studies are needed to unravel the mechanistic links and find the correlation between expressions of these genes and the pathological stage of periodontitis.
牙周炎是一种常见的口腔疾病，在世界发达国家和发展中国家都会导致牙齿脱落。这种多因素疾病与多种分子途径的异常活动有关，其中包括与催产素相关的途径。在本研究中，我们招募了26名患者和28名对照，并用实时PCR评估了所招募个体的循环系统和患病组织中4种与催产素相关基因的表达，即[此处原文缺失基因名称]、[此处原文缺失基因名称]、[此处原文缺失基因名称]和[此处原文缺失基因名称]。与总对照组织相比，[此处原文缺失基因名称]在全牙周炎组织中的表达下调[平均表达比值（RME）=0.23，P值=0.03]。与总对照相比，患者全血样本中[此处原文缺失基因名称]的表达也较低。与总对照组织相比，[此处原文缺失基因名称]在全牙周炎组织中的表达下调（RME = 0.16，P值=0.01）。此外，与对照相比，患者全血样本中[此处原文缺失基因名称]的表达降低（RME = 0.25，P值=0.03）。与总对照组织相比，[此处原文缺失基因名称]在全牙周炎组织中的表达下调（RME = 0.17，P值=0.01）。然而，患病个体与未患病个体的血液样本中[此处原文缺失基因名称]的表达没有差异。最后，与总对照组织相比，[此处原文缺失基因名称]在全牙周炎组织中的表达较低（RME = 0.24，P值=0.01），与对照相比，患病个体全血样本中[此处原文缺失基因名称]的表达较低（RME = 0.42，P值=0.05）。本研究提供了与催产素相关基因表达和牙周炎存在之间关联的数据。未来需要进一步研究来阐明其机制联系，并找出这些基因表达与牙周炎病理阶段之间的相关性。
