Souto José A, Stockman Robert A, Ley Steven V
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Org Biomol Chem. 2015 Apr 7;13(13):3871-7. doi: 10.1039/c5ob00170f.
A method for the continuous preparation of alcohols by hydroboration/oxidation of olefins using flow techniques is described. The process allows the isolation of up to 120 mmol h(-1) of the desired alcohol in a very rapid manner with good functional group tolerance. The flow setup can be modified to perform a continuous extraction of the desired alcohol from the biphasic mixture produced by the reaction.
描述了一种使用流动技术通过烯烃的硼氢化/氧化连续制备醇的方法。该方法能够以非常快速的方式分离出高达120 mmol h⁻¹的所需醇，并且对官能团具有良好的耐受性。流动装置可以进行改进，以从反应产生的双相混合物中连续萃取所需的醇。
