The Effect of Irrigation Solutions on the Setting Time, Solubility, and pH of Three Types of Premixed Bioceramic-Based Root Canal Sealers.

Calcium silicate- and strontium (Sr) silicate-based sealers are hydraulic materials that require moisture to initiate and complete the setting reaction. This study evaluated the effects of various irrigants on the setting time, solubility, and pH of premixed bioceramic sealers. The sealers investigated in this study were CeraSeal (CS), C-Root (CR) SP, and KP-Root (KPR) SP. Setting time was assessed in accordance with ISO 6876:2012 ( = 6). For solubility and pH ( = 6), sealers were placed in molds and set for 1.5 times the setting time previously determined in the experimental setting time assessment. The free surfaces of the sealers were then exposed to sodium hypochlorite (NaOCl), chlorhexidine (CHX), normal saline, or distilled water (DW) for 1 min. Solubility and pH values were measured at 1, 7, 14, 21, and 28 days. KPR SP showed the highest pH and solubility in CHX and NaOCl. CS exhibited the lowest solubility and shortest setting time, while CR SP had the highest initial solubility and the longest setting time under dry conditions. Irrigating solutions significantly affected the sealers' setting and dissolution behavior. Sr- containing sealers, such as KPR SP and CR SP, showed increased interaction with CHX and NaOCl, highlighting the importance of material composition in clinical performance.