Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China.
MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China.
Diabetes Care. 2015 Mar;38(3):529-37. doi: 10.2337/dc14-2073.
It remains unclear how many hours of sleep are associated with the lowest risk of type 2 diabetes. This meta-analysis was performed to assess the dose-response relationship between sleep duration and risk of type 2 diabetes.
PubMed and Embase were searched up to 20 March 2014 for prospective observational studies that assessed the relationship of sleep duration and risk of type 2 diabetes. Both semiparametric and parametric methods were used.
Ten articles with 11 reports were eligible for inclusion in the meta-analysis. A total of 18,443 incident cases of type 2 diabetes were ascertained among 482,502 participants with follow-up periods ranging from 2.5 to 16 years. A U-shaped dose-response relationship was observed between sleep duration and risk of type 2 diabetes, with the lowest risk observed at a sleep duration category of 7-8 h per day. Compared with 7-h sleep duration per day, the pooled relative risks for type 2 diabetes were 1.09 (95% CI 1.04-1.15) for each 1-h shorter sleep duration among individuals who slept <7 h per day and 1.14 (1.03-1.26) for each 1-h increment of sleep duration among individuals with longer sleep duration.
Our dose-response meta-analysis of prospective studies shows a U-shaped relationship between sleep duration and risk of type 2 diabetes, with the lowest type 2 diabetes risk at 7-8 h per day of sleep duration. Both short and long sleep duration are associated with a significantly increased risk of type 2 diabetes, underscoring the importance of appropriate sleep duration in the delay or prevention of type 2 diabetes.
目前尚不清楚与 2 型糖尿病风险最低相关的睡眠时间是多少。本荟萃分析旨在评估睡眠时间与 2 型糖尿病风险之间的剂量反应关系。
截至 2014 年 3 月 20 日，我们在 PubMed 和 Embase 上检索了评估睡眠时间与 2 型糖尿病风险之间关系的前瞻性观察性研究。使用半参数和参数方法。
共有 10 篇文章的 11 份报告符合纳入荟萃分析的标准。在 482502 名参与者中，共有 18443 例 2 型糖尿病新发病例，随访时间从 2.5 年到 16 年不等。睡眠时间与 2 型糖尿病风险之间存在 U 形剂量反应关系，每天睡眠时间为 7-8 小时时风险最低。与每天 7 小时睡眠时间相比，每天睡眠时间减少 1 小时，2 型糖尿病的合并相对风险为 1.09（95%CI 1.04-1.15）；每天睡眠时间增加 1 小时，2 型糖尿病的合并相对风险为 1.14（1.03-1.26）。
我们对前瞻性研究的剂量反应荟萃分析显示，睡眠时间与 2 型糖尿病风险之间呈 U 形关系，每天睡眠时间为 7-8 小时时 2 型糖尿病风险最低。短时间和长时间睡眠都会显著增加 2 型糖尿病的风险，这突显了适当的睡眠时间对于延迟或预防 2 型糖尿病的重要性。
