Ostojic Sergej M
Biomedical Sciences Department, Faculty of Sport and PE, University of Novi Sad, Serbia; Bioenergetics Unit, Center for Health, Exercise and Sport Sciences, Stari DIF, Belgrade, Serbia.
Pharmacol Res. 2015 Apr;94:51-3. doi: 10.1016/j.phrs.2015.02.004. Epub 2015 Feb 24.
Although the administration of molecular hydrogen (H2, dihydrogen) has been recognized as an effective innovative therapeutic procedure in biomedicine, H2 cellular kinetics and utilization seems to be less understood. In particular, mitochondrial barriers might impact on H2 use in mitochondria-related diseases and conditions. Double-membrane organization of mitochondria and large membrane potential are important elements of mitochondrial stability that control the transport of the molecule into and out of the organelle. In this perspective paper, we advanced possible obstacles and advantages for H2 delivery to mitochondria.
尽管分子氢（H₂，氢气）的施用已被公认为生物医学中一种有效的创新治疗方法，但H₂的细胞动力学和利用情况似乎仍未得到充分了解。特别是，线粒体屏障可能会影响H₂在与线粒体相关的疾病和病症中的应用。线粒体的双膜结构和大的膜电位是线粒体稳定性的重要因素，它们控制着分子进出细胞器的运输。在这篇观点论文中，我们提出了H₂输送到线粒体的可能障碍和优势。
