Wysowski D K, Baum C
Division of Epidemiology and Surveillance, Food and Drug Administration, Rockville, Md.
Arch Gen Psychiatry. 1989 Oct;46(10):929-32. doi: 10.1001/archpsyc.1989.01810100071013.
Data from the National Prescription Audit and the National Disease and Therapeutic Index were used to assess trends in outpatient prescriptions for antipsychotic drugs in the United States from 1976 to 1985. Retail pharmacies dispensed 21 million prescriptions for antipsychotic drugs in 1976 and 19 million in 1985. The three leading antipsychotic drugs-thioridazine, haloperidol, and chlorpromazine-constituted 66% to 69% of antipsychotic prescriptions and, along with trifluoperazine, thiothixene, and fluphenazine, accounted for 90% to 91% of all antipsychotic prescriptions throughout the period studied. Thioridazine was the leading medication, with a consistent third of the market share, while the market share for chlorpromazine decreased from 1976 to 1985 and that for haloperidol increased for the same years. Data also indicate that haloperidol is the antipsychotic drug used most frequently in office-based, private medical practice for patients 60 years of age and older, a declining proportion of women are treated with antipsychotic medications, and use of antipsychotic drugs as monotherapy for the primary diagnosis is increasing. We also obtained data on diagnoses associated with antipsychotic drug use.
利用来自国家处方审计和国家疾病与治疗指数的数据，评估了1976年至1985年美国抗精神病药物门诊处方的趋势。1976年零售药店配出了2100万张抗精神病药物处方，1985年为1900万张。三种主要的抗精神病药物——硫利达嗪、氟哌啶醇和氯丙嗪——占抗精神病药物处方的66%至69%，在整个研究期间，与三氟拉嗪、替沃噻吨和氟奋乃静一起，占所有抗精神病药物处方的90%至91%。硫利达嗪是主要药物，市场份额始终占三分之一，而氯丙嗪的市场份额在1976年至1985年期间下降，氟哌啶醇的市场份额在同几年中上升。数据还表明，氟哌啶醇是60岁及以上患者在基于办公室的私人医疗实践中最常使用的抗精神病药物，接受抗精神病药物治疗的女性比例在下降，并且作为主要诊断的单一疗法使用抗精神病药物的情况正在增加。我们还获得了与抗精神病药物使用相关的诊断数据。
