电针对成年大鼠损伤脊髓内源性神经干细胞和少突胶质细胞的增殖作用。
Electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in the injured spinal cord of adult rats.
机构信息
Department of Emergency and Intensive Care Unit, First Affiliated Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China.
Kunming University, Kunming 650118, Yunnan Province, China.
出版信息
Neural Regen Res. 2012 May 25;7(15):1138-44. doi: 10.3969/j.issn.1673-5374.2012.15.003.
A contusive model of spinal cord injury at spinal segment T8-9 was established in rats. Huantiao (GB30) and Huatuojiaji (Ex-B05) were punctured with needles, and endogenous neural stem cells were labeled with 5-bromo-2'-deoxyuridine (BrdU) and NG2. Double immunofluorescence staining showed that electroacupuncture markedly increased the numbers of BrdU(+)/NG2(+) cells at spinal cord tissue 15 mm away from the injury center in the rostral and caudal directions. The results suggest that electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in rats with spinal cord injury.
在大鼠 T8-9 脊髓损伤部位建立了挫伤模型。针刺环跳（GB30）和华佗夹脊穴（Ex-B05），并用 5-溴-2'-脱氧尿苷（BrdU）和 NG2 标记内源性神经干细胞。双重免疫荧光染色显示，电针对损伤中心 15mm 处的脊髓组织中 BrdU（+）/NG2（+）细胞的数量有显著增加。结果表明，电针对脊髓损伤大鼠内源性神经干细胞和少突胶质细胞的增殖有促进作用。
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