Komeili Gholamreza, Hashemi Mohammad, Bameri-Niafar Mohsen
Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43181, Iran.
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43181, Iran.
Cholesterol. 2016;2016:7389864. doi: 10.1155/2016/7389864. Epub 2016 Apr 14.
The present study was carried out to investigate the antidiabetic and antihyperlipidemic properties of hydroalcoholic extract of Peganum harmala in streptozotocin-induced diabetic male rats. In an experimental study, 64 normal Wistar albino male rats (200-230 g) were randomly divided into 8 groups. Control and diabetic rats were treated with normal saline and three different doses (30, 60, and 120 mg/kg) of hydroalcoholic extract of Peganum harmala seeds for 4 weeks orally. At the end of treatment, blood samples were taken and glucose, triglycerides, total cholesterol, LDL-c, HDL-c, malondialdehyde (MDA), total antioxidant capacity (TCA), ALT, AST, GGT, bilirubin, and glycosylated hemoglobin (HbA1C) were determined. STZ-induced diabetic rats showed significant changes in the values of glucose, triglycerides, total cholesterol, LDL-c, MDA, TAC, ALT, AST, GGT, bilirubin, and HbA1C in comparison with normal rats. Administration of the extract to diabetic rats resulted in a remarkable decrease in glucose, lipid profiles, MDA, ALT, AST, GGT, bilirubin, and HbA1C levels and increase in TAC relative to diabetic group. The results of this study indicated that hydroalcoholic extract of Peganum harmala seeds possesses antidiabetic and hypolipidemic activities and could be useful in treatment of diabetes.
本研究旨在探讨骆驼蓬水醇提取物对链脲佐菌素诱导的糖尿病雄性大鼠的抗糖尿病和抗高血脂特性。在一项实验研究中，将64只正常的Wistar白化雄性大鼠（200 - 230克）随机分为8组。对照组和糖尿病大鼠分别口服生理盐水和三种不同剂量（30、60和120毫克/千克）的骆驼蓬种子水醇提取物，持续4周。治疗结束时，采集血样并测定血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、丙二醛（MDA）、总抗氧化能力（TCA）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、γ-谷氨酰转移酶（GGT）、胆红素和糖化血红蛋白（HbA1C）。与正常大鼠相比，链脲佐菌素诱导的糖尿病大鼠在血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、MDA、TAC、ALT、AST、GGT、胆红素和HbA1C值方面表现出显著变化。给糖尿病大鼠服用提取物后，与糖尿病组相比，血糖、血脂谱、MDA、ALT、AST、GGT、胆红素和HbA1C水平显著降低，TAC升高。本研究结果表明，骆驼蓬种子水醇提取物具有抗糖尿病和降血脂活性，可用于糖尿病的治疗。
