Deahl M
Maudsley Hospital, Denmark Hill, London, England.
Mov Disord. 1989;4(4):330-2. doi: 10.1002/mds.870040406.
Two cases are described of chronic schizophrenic patients maintained on depot neuroleptics, who developed severe extrapyramidal symptoms following a period of heavy betel nut consumption. A mechanism for this effect is proposed based on the pharmacological antagonism of the anticholinergic agent, procyclidine, by the active alkaloid ingredient of the betel, arecoline.
本文描述了两例长期使用长效抗精神病药物的慢性精神分裂症患者，他们在大量食用槟榔一段时间后出现了严重的锥体外系症状。基于槟榔的活性生物碱成分槟榔碱对抗胆碱能药物丙环定的药理拮抗作用，提出了这种效应的机制。
