Department of Pharmacy, College of Pharmacy, Alzaytoonah University of Jordan, 11734 Amman, Jordan.
Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, Busan 47392, Korea.
Int J Mol Sci. 2019 Aug 31;20(17):4274. doi: 10.3390/ijms20174274.
Enzymes in the cytochrome P450 4 (CYP4) family are involved in the metabolism of fatty acids, xenobiotics, therapeutic drugs, and signaling molecules, including eicosanoids, leukotrienes, and prostanoids. As CYP4 enzymes play a role in the maintenance of fatty acids and fatty-acid-derived bioactive molecules within a normal range, they have been implicated in various biological functions, including inflammation, skin barrier, eye function, cardiovascular health, and cancer. Numerous studies have indicated that genetic variants of genes cause inter-individual variations in metabolism and disease susceptibility. Genetic variants of , genes are associated with cardiovascular diseases. Mutations of , , and other genes that generate 20-HETE are a potential risk for cancer. gene variants are associated with ocular disease, while those of are linked to skin disease and is associated with the inflammatory response. The present study comprehensively collected research to provide an updated view of the molecular functionality of genes and their associations with human diseases. Functional analysis of genes with clinical implications is necessary to understand inter-individual variations in disease susceptibility and for the development of alternative treatment strategies.
细胞色素 P4504 家族中的酶参与脂肪酸、外源性化学物质、治疗药物和信号分子（包括类二十烷酸、白三烯和前列腺素）的代谢。由于 CYP4 酶在维持脂肪酸和脂肪酸衍生的生物活性分子的正常范围内发挥作用，它们与各种生物学功能有关，包括炎症、皮肤屏障、眼睛功能、心血管健康和癌症。许多研究表明，基因的遗传变异导致个体间代谢和疾病易感性的差异。基因的遗传变异与心血管疾病有关。产生 20-HETE 的基因的突变，如 、 、和其他基因，是癌症的潜在风险。基因变异与眼部疾病有关，而 基因的变异与皮肤疾病有关， 基因与炎症反应有关。本研究全面收集了研究资料，提供了基因及其与人类疾病关联的分子功能的最新观点。对具有临床意义的基因进行功能分析，对于理解疾病易感性的个体差异和开发替代治疗策略是必要的。
