Maartens Aidan P, Brown Nicholas H
Department of Physiology, Development and Neuroscience, The Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.
Department of Physiology, Development and Neuroscience, The Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.
Curr Top Dev Biol. 2015;112:233-72. doi: 10.1016/bs.ctdb.2014.11.020. Epub 2015 Feb 11.
Integrins mediate cell adhesion by providing a link between the actin cytoskeleton and the extracellular matrix. As well as acting to anchor cells, integrin adhesions provide sensory input via mechanotransduction and synergism with signaling pathways, and provide the cell with the conditions necessary for differentiation in a permissive manner. In this review, we explore how integrins contribute to development, and what this tells us about how they work. From a signaling perspective, the influence of integrins on cell viability and fate is muted in a developmental context as compared to cell culture. Integrin phenotypes tend to arise from a failure of normally specified cells to create tissues properly, due to defective adhesion. The diversity of integrin functions in development shows how cell adhesion is continuously adjusted, both within and between animals, to fit developmental purpose.
整合素通过在肌动蛋白细胞骨架和细胞外基质之间建立联系来介导细胞黏附。除了起到锚定细胞的作用外，整合素黏附还通过机械转导和与信号通路的协同作用提供感觉输入，并以允许的方式为细胞提供分化所需的条件。在本综述中，我们探讨整合素如何促进发育，以及这能告诉我们它们是如何工作的。从信号传导的角度来看，与细胞培养相比，整合素在发育环境中对细胞活力和命运的影响较小。整合素表型往往源于正常指定的细胞由于黏附缺陷而无法正确形成组织。整合素在发育中的功能多样性表明，无论是在动物体内还是动物之间，细胞黏附是如何不断调整以适应发育目的的。
