Kırış Abdulkadir, Turan Oğuzhan Ekrem, Kırış Gülhanım, İlter Abdulselam, Öztürk Mustafa, Aydın Mesut, Kaplan Şahin, Kutlu Merih, Gedikli Ömer
Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Kardiol Pol. 2015;73(7):527-32. doi: 10.5603/KP.a2015.0025. Epub 2015 Mar 3.
Ventricular premature beats (VPBs) are one of the most common rhythm abnormalities. Structural heart diseases such as myocardial hypertrophy and left ventricular dysfunction are associated with VPBs. However, the exact mechanism of VPBs in patients without structural heart disease has not been revealed yet. Epicardial fat tissue (EFT) is a visceral fat around the heart. Increased EFT thickness is associated with myocardial structural and ultrastructural myocardial abnormalities, which may play a role in the development of VPBs.
To evaluate the possible relationship between EFT thickness and frequent VPBs.
The study population consisted of 50 patients with VPBs and 50 control subjects. Frequent VPBs were defined as the presence of more than 10 beats per hour assessed by 24-h Holter electrocardiography monitoring. EFT thickness was measured by transthoracic echocardiography. Multivariable logistic regression analysis was used to assess factors related with frequent VPBs. Baseline demographic and biochemical features including age, gender, and rates of hypertension and diabetes mellitus were similar in both groups. EFT thickness was significantly higher in patients with frequent VPBs than in controls (3.3 ± 1.3 mm vs. 2.2 ± 0.8 mm, p < 0.001). In multivariable logistic regression analysis, EFT thickness was independently associated with VPB frequency (B = 1.030, OR = 2.802, p < 0.001).
Patients with frequent VPBs had increased EFT thickness compared to control subjects. EFT thickness was independently associated with frequent VPBs.
室性早搏（VPB）是最常见的心律失常之一。心肌肥厚和左心室功能障碍等结构性心脏病与室性早搏有关。然而，无结构性心脏病患者室性早搏的确切机制尚未明确。心外膜脂肪组织（EFT）是心脏周围的内脏脂肪。EFT厚度增加与心肌结构及超微结构异常有关，这可能在室性早搏的发生中起作用。
评估EFT厚度与频发室性早搏之间的可能关系。
研究人群包括50例室性早搏患者和50例对照者。频发室性早搏定义为通过24小时动态心电图监测每小时出现超过10次早搏。EFT厚度通过经胸超声心动图测量。采用多变量逻辑回归分析评估与频发室性早搏相关的因素。两组的基线人口统计学和生化特征，包括年龄、性别、高血压和糖尿病发生率相似。频发室性早搏患者的EFT厚度显著高于对照组（3.3±1.3mm对2.2±0.8mm，p<0.001）。在多变量逻辑回归分析中，EFT厚度与室性早搏频率独立相关（B = 1.030，OR = 2.802，p<0.001）。
与对照者相比，频发室性早搏患者的EFT厚度增加。EFT厚度与频发室性早搏独立相关。
