Vargas M L, Martinez J A, Milanés M V
Eur J Pharmacol. 1986 Sep 9;128(3):259-63. doi: 10.1016/0014-2999(86)90774-0.
Apomorphine or bromocriptine treatment at doses that act on dopamine autoreceptors resulted in a significant elevation of the release of opioid peptides from the myenteric plexus of guinea-pig, since these drugs produced an increase of the inhibitory response which was reversed by naloxone. 6-Hydroxydopamine treatment also resulted in an increase in opioid peptide release. These findings would indicate that the interruption of dopaminergic transmission in the myenteric plexus produces an increase in the release of opioid peptides and suggest an inhibitory modulation of opioid peptidergic neurons by dopamine systems at this level.
作用于多巴胺自身受体剂量的阿扑吗啡或溴隐亭治疗导致豚鼠肌间神经丛中阿片肽释放显著升高，因为这些药物使抑制性反应增强，而纳洛酮可逆转这种增强。6-羟基多巴胺治疗也导致阿片肽释放增加。这些发现表明，肌间神经丛中多巴胺能传递的中断会使阿片肽释放增加，并提示在该水平多巴胺系统对阿片肽能神经元存在抑制性调节作用。
