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英国髋部骨折人群健康相关生活质量的恢复。华威髋部创伤评估——一项前瞻性队列研究。

Recovery of health-related quality of life in a United Kingdom hip fracture population. The Warwick Hip Trauma Evaluation--a prospective cohort study.

作者信息

Griffin X L, Parsons N, Achten J, Fernandez M, Costa M L

机构信息

University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.

University Hospitals Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry CV2 2DX, UK.

出版信息

Bone Joint J. 2015 Mar;97-B(3):372-82. doi: 10.1302/0301-620X.97B3.35738.

Abstract

Hip fracture is a global public health problem. The National Hip Fracture Database provides a framework for service evaluation in this group of patients in the United Kingdom, but does not collect patient-reported outcome data and is unable to provide meaningful data about the recovery of quality of life. We report one-year patient-reported outcomes of a prospective cohort of patients treated at a single major trauma centre in the United Kingdom who sustained a hip fracture between January 2012 and March 2014. There was an initial marked decline in quality of life from baseline measured using the EuroQol 5 Dimensions score (EQ-5D). It was followed by a significant improvement to 120 days for all patients. Although their quality of life improved during the year after the fracture, it was still significantly lower than before injury irrespective of age group or cognitive impairment (mean reduction EQ-5D 0.22; 95% confidence interval (CI) 0.17 to 0.26). There was strong evidence that quality of life was lower for patients with cognitive impairment. There was a mean reduction in EQ-5D of 0.28 (95% CI 0.22 to 0.35) in patients < 80 years of age. This difference was consistent (and fixed) throughout follow-up. Quality of life does not improve significantly during recovery from hip fracture in patients over 80 years of age (p = 0.928). Secondary measures of function showed similar trends. Hip fracture marks a step down in the quality of life of a patient: it accounts for approximately 0.22 disability adjusted life years in the first year after fracture. This is equivalent to serious neurological conditions for which extensive funding for research and treatment is made available.

摘要

髋部骨折是一个全球性的公共卫生问题。国家髋部骨折数据库为英国这类患者的服务评估提供了一个框架,但不收集患者报告的结局数据,也无法提供有关生活质量恢复的有意义数据。我们报告了在英国一家主要创伤中心接受治疗的前瞻性队列患者的一年期患者报告结局,这些患者在2012年1月至2014年3月期间发生了髋部骨折。使用欧洲五维健康量表(EQ-5D)评分从基线测量的生活质量最初有明显下降。随后所有患者在120天时显著改善。尽管骨折后一年内他们的生活质量有所改善,但无论年龄组或认知障碍如何,仍显著低于受伤前(EQ-5D平均降低0.22;95%置信区间(CI)0.17至0.26)。有强有力的证据表明认知障碍患者的生活质量较低。80岁以下患者的EQ-5D平均降低0.28(95%CI 0.22至0.35)。这种差异在整个随访过程中是一致的(且固定不变)。80岁以上患者髋部骨折恢复期间生活质量没有显著改善(p = 0.928)。功能的次要指标显示出类似趋势。髋部骨折标志着患者生活质量下降:在骨折后的第一年约占0.22个伤残调整生命年。这相当于严重的神经系统疾病,为此提供了大量的研究和治疗资金。

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