外泌体通讯迅速传播。
Exosomal communication goes viral.
作者信息
Meckes David G
机构信息
Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, USA
出版信息
J Virol. 2015 May;89(10):5200-3. doi: 10.1128/JVI.02470-14. Epub 2015 Mar 4.
Abstract
Exosomes are small vesicles secreted from cells that participate in intercellular communication events. Accumulating evidence demonstrates that host exosome pathways are hijacked by viruses and that virally modified exosomes contribute to virus spread and immune evasion. In the case of tumor viruses, recent findings suggest that alterations in normal exosome biology may promote the development and progression of cancer. These studies will be discussed in the context of our current knowledge of Epstein-Barr virus (EBV)-modified exosomes.
摘要
外泌体是细胞分泌的小囊泡，参与细胞间通讯事件。越来越多的证据表明，宿主外泌体途径被病毒劫持，并且病毒修饰的外泌体有助于病毒传播和免疫逃逸。就肿瘤病毒而言，最近的研究结果表明，正常外泌体生物学的改变可能促进癌症的发生和发展。这些研究将在我们目前对爱泼斯坦-巴尔病毒（EBV）修饰的外泌体的了解背景下进行讨论。
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本文引用的文献
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Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.癌症外泌体可进行非细胞依赖的微小RNA生物合成并促进肿瘤发生。
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Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes.外泌体 HIF1α 支持与鼻咽癌相关的 LMP1 阳性外泌体的侵袭潜力。
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Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells.外泌体介导的人肝癌细胞 Huh7.5 之间丙型肝炎病毒的传播。
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Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveola-dependent endocytosis and promote phenotypic modulation in target cells.源自 Epstein-Barr 病毒感染细胞的外泌体通过网格蛋白依赖的内吞作用被内化，并促进靶细胞的表型调节。
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Modulation of B-cell exosome proteins by gamma herpesvirus infection.γ 疱疹病毒感染对 B 细胞外泌体蛋白的调节作用。
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Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells.在 B 细胞和上皮细胞中，EB 病毒潜伏 I、II 和 III 期间，组成性干扰素诱导蛋白 16-炎症小体的激活。
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Exosomes released in vitro from Epstein-Barr virus (EBV)-infected cells contain EBV-encoded latent phase mRNAs.体外释放的源自 Epstein-Barr 病毒 (EBV) 感染细胞的外泌体包含 EBV 编码的潜伏阶段 mRNAs。
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A pathogenic picornavirus acquires an envelope by hijacking cellular membranes.一种致病小核糖核酸病毒通过劫持细胞膜获得包膜。
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