Meckes David G
Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, USA
J Virol. 2015 May;89(10):5200-3. doi: 10.1128/JVI.02470-14. Epub 2015 Mar 4.
Exosomes are small vesicles secreted from cells that participate in intercellular communication events. Accumulating evidence demonstrates that host exosome pathways are hijacked by viruses and that virally modified exosomes contribute to virus spread and immune evasion. In the case of tumor viruses, recent findings suggest that alterations in normal exosome biology may promote the development and progression of cancer. These studies will be discussed in the context of our current knowledge of Epstein-Barr virus (EBV)-modified exosomes.
外泌体是细胞分泌的小囊泡，参与细胞间通讯事件。越来越多的证据表明，宿主外泌体途径被病毒劫持，并且病毒修饰的外泌体有助于病毒传播和免疫逃逸。就肿瘤病毒而言，最近的研究结果表明，正常外泌体生物学的改变可能促进癌症的发生和发展。这些研究将在我们目前对爱泼斯坦-巴尔病毒（EBV）修饰的外泌体的了解背景下进行讨论。
