从大脑中进行cDNA克隆所揭示的甲状腺素运载蛋白mRNA的脑特异性表达。
Brain-specific expression of transthyretin mRNA as revealed by cDNA cloning from brain.
作者信息
Motojima K, Goto S
机构信息
Department of Biochemistry, School of Pharmaceutical Sciences, Toho University, Chiba, Japan.
出版信息
FEBS Lett. 1989 Nov 20;258(1):103-5. doi: 10.1016/0014-5793(89)81625-4.
PMID:2574113
Abstract
cDNAs for rat transthyretin mRNA were cloned from a brain cDNA library. Sequencing analyses showed the presence of an additional 5' sequence that had not been reported for the liver mRNA corresponding to the flanking promoter region of the gene. This additional sequence was expressed only in the brain, suggesting the presence of a brain-specific promoter.
摘要
从大鼠脑cDNA文库中克隆了甲状腺素运载蛋白mRNA的cDNA。序列分析表明，存在一个额外的5'序列，该序列在对应于该基因侧翼启动子区域的肝脏mRNA中未被报道。这个额外的序列仅在脑中表达，提示存在一个脑特异性启动子。
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