Kamal Atif, Cincinelli Alessandra, Martellini Tania, Palchetti Ilaria, Bettazzi Francesca, Malik Riffat Naseem
a Environmental Biology and Ecotoxicology Laboratory, Department of Environmental Sciences, Faculty of Biological Sciences , Quaid-I-Azam University , Islamabad , Pakistan.
b Department of Chemistry , University of Florence , Florence , Italy.
Int J Environ Health Res. 2016;26(1):37-57. doi: 10.1080/09603123.2015.1007843. Epub 2015 Mar 5.
This study presents the analyses of urinary biomarkers (1-OHPyr, α- and β-naphthols) of polycyclic aromatic hydrocarbons (PAHs) exposure and biomarkers of effect (i.e. blood parameters) in petroleum-refinery workers (RFs) and auto-repair workers (MCs). Exposed subjects had higher concentrations of white blood cell (WBC) count than control subjects (CN) subjects (5.31 × 10(3) μL(-1) in exposed vs. 5.15 × 10(3) μL(-1) in CN subjects), while the biomarker of oxidative DNA damage (8-OHdG) was significantly higher in MCs. The exposure among these two cohorts could be influenced by the ambience of the workplaces; in fact, MCs' shops are relatively damp and enclosed workplaces in comparison with the indoor environment of refineries. PAHs in the dust samples from mechanical workshops probably originated from mixed sources (traffic exhaust and petroleum spills), while the incremental lifetime cancer risk (ILCR) for MCs showed moderate-to-low cancer risk from exposure to dust-bound PAHs. The study shows that increasing PAH exposure can be traced in MC workstations and needs to be investigated for the safety of public health.
本研究对石油精炼工人（RFs）和汽车修理工人（MCs）中多环芳烃（PAHs）暴露的尿液生物标志物（1-OHPyr、α-和β-萘酚）以及效应生物标志物（即血液参数）进行了分析。暴露组受试者的白细胞（WBC）计数浓度高于对照组受试者（CN）（暴露组为5.31×10³μL⁻¹，CN组为5.15×10³μL⁻¹），而MCs中氧化DNA损伤的生物标志物（8-OHdG）显著更高。这两个队列中的暴露情况可能受工作场所环境的影响；事实上，与炼油厂的室内环境相比，MCs的车间相对潮湿且封闭。机械车间灰尘样本中的PAHs可能源自混合源（交通尾气和石油泄漏），而MCs因接触与灰尘结合的PAHs的终生癌症风险增量（ILCR）显示为中度至低度癌症风险。该研究表明，在MCs工作场所可发现PAH暴露增加的情况，为了公众健康安全需要对此进行调查。
