血清可溶性晚期糖基化终末产物受体水平与颈动脉粥样硬化：北曼哈顿研究（NOMAS）
Serum soluble RAGE levels and carotid atherosclerosis: the Northern Manhattan Study (NOMAS).
作者信息
Hudson Barry I, Gardener Hannah, Liu-Mares Wen, Dong Chuanhui, Cheung Ken, Elkind Mitchell S V, Wright Clinton B, Sacco Ralph L, Rundek Tatjana
机构信息
Division of Endocrinology, Diabetes & Metabolism, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
出版信息
Atherosclerosis. 2015 May;240(1):17-20. doi: 10.1016/j.atherosclerosis.2015.02.015. Epub 2015 Feb 24.
BACKGROUND
Recent cohort studies suggested that serum levels of soluble Receptor for Advanced Glycation End-products (sRAGE) are associated with the risk of cardiovascular disease. We hypothesized that sRAGE levels are associated with subclinical atherosclerosis in a racially and ethnically diverse population.
METHODS AND RESULTS
828 stroke-free participants from the Northern Manhattan Study (mean age 71.1±8.7yrs; 64% Hispanic, 19% black, and 17% white) underwent high-resolution carotid B-mode ultrasound to measure carotid plaque (present in 62% of subjects) and intima-media thickness (IMT) (mean Total=0.96±0.10 mm). Serum sRAGE was measured by ELISA and associations tested between sRAGE with IMT and plaque presence. Soluble RAGE levels were not associated with plaque presence or IMT after adjusting for sociodemographic, vascular risk factors and medication use. Stratification by race-ethnicity did not reveal any associations with carotid IMT or plaque.
CONCLUSION
In the present study, sRAGE levels were not associated with carotid atherosclerosis.
背景
近期队列研究表明，血清晚期糖基化终产物可溶性受体（sRAGE）水平与心血管疾病风险相关。我们推测，在种族和民族多样化人群中，sRAGE水平与亚临床动脉粥样硬化相关。
方法与结果
来自北曼哈顿研究的828名无中风参与者（平均年龄71.1±8.7岁；64%为西班牙裔，19%为黑人，17%为白人）接受了高分辨率颈动脉B型超声检查，以测量颈动脉斑块（62%的受试者存在）和内膜中层厚度（IMT）（平均总厚度=0.96±0.10毫米）。通过酶联免疫吸附测定法测量血清sRAGE，并测试sRAGE与IMT及斑块存在之间的关联。在调整社会人口统计学、血管危险因素和药物使用情况后，可溶性RAGE水平与斑块存在或IMT无关。按种族-民族分层未显示与颈动脉IMT或斑块有任何关联。
结论
在本研究中，sRAGE水平与颈动脉粥样硬化无关。
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