Wen Zhongmin, Wang Peiji
Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China.
Department of Orthopedics, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China.
Neural Regen Res. 2012 Mar 15;7(8):578-82. doi: 10.3969/j.issn.1673-5374.2012.08.003.
The cerebral cortical expansion index refers to the ratio between left and right cortex width and is recognized as an indicator for cortical hyperplasia. Cerebral ischemia was established in CB-17 mice in the present study, and the mice were subsequently treated with recombinant human erythropoietin via subcutaneous injection. Results demonstrated that cerebral cortical width index significantly increased. Immunofluorescence detection showed that the number of nuclear antigen antibody/5-bromodeoxyuridine-positive cells at the infarction edge significantly increased. Correlation analysis revealed a negative correlation between neurological scores and cortical width indices in rats following ischemic stroke. These experimental findings suggested that recombinant human erythropoietin promoted cerebral cortical hyperplasia, increased cortical neurogenesis, and enhanced functional recovery following ischemic stroke.
大脑皮质扩张指数是指左右皮质宽度之比，被认为是皮质增生的一个指标。在本研究中，在CB - 17小鼠中建立脑缺血模型，随后通过皮下注射用重组人促红细胞生成素对小鼠进行治疗。结果表明，大脑皮质宽度指数显著增加。免疫荧光检测显示，梗死边缘的核抗原抗体/5-溴脱氧尿苷阳性细胞数量显著增加。相关性分析显示，缺血性中风后大鼠的神经功能评分与皮质宽度指数呈负相关。这些实验结果表明，重组人促红细胞生成素可促进大脑皮质增生，增加皮质神经发生，并增强缺血性中风后的功能恢复。
