南川波罗蜜中的新型芪类化合物。

Novel stilbenes from Artocarpus nanchuanensis.

作者信息

Zhang Pu-Zhao, Gu Jian, Zhang Guo-Lin

机构信息

a Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 , China.

出版信息

J Asian Nat Prod Res. 2015;17(3):217-23. doi: 10.1080/10286020.2015.1006202. Epub 2015 Mar 9.

DOI:10.1080/10286020.2015.1006202

PMID:25747599

Abstract

Four new stilbene derivatives, hypargystilbenes B-E (1-4), together with seven known compounds (5-11), were isolated from the stems of Artocarpus nanchuanensis S.S. Chang. Their structures were elucidated on the basis of spectral data. Hypargystilbene B, hypargystilbene D, and hypargystilbene E exhibited protein tyrosine phosphatase 1B inhibitory effects with corresponding IC50 values of 3.23, 37.31, and 2.53 nM.

摘要

从南川波罗蜜（Artocarpus nanchuanensis S.S. Chang）的茎中分离出4个新的芪衍生物，即隐波罗蜜芪B - E（1 - 4），以及7个已知化合物（5 - 11）。基于光谱数据阐明了它们的结构。隐波罗蜜芪B、隐波罗蜜芪D和隐波罗蜜芪E表现出对蛋白酪氨酸磷酸酶1B的抑制作用，相应的IC50值分别为3.23、37.31和2.53 nM。