Bionanosystem Engineering Department, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Bionanosystem Engineering Department, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Int J Biol Macromol. 2015;77:1-8. doi: 10.1016/j.ijbiomac.2015.02.044. Epub 2015 Mar 5.
Post-menopausal wound care management is a substantial burden on health services, since there are an increased number of elderly populations linked with age-related delayed wound healing. The controlled estrogen replacement can accelerate healing of acute cutaneous wounds, linked to its potent anti-inflammatory activity. The electrospinning technique can be used to introduce the desired therapeutic agents to the nanofiber matrix. So here we introduce a new material for wound tissue dressing, in which a polyurethane-dextran composite nanofibrous wound dressing material loaded with β-estradiol was obtained through electrospinning. Dextran can promote neovascularization and skin regeneration in chronic wounds. This study involves the characterization of these nanofibers and analysis of cell growth and proliferation to determine the efficiency of tissue regeneration on these biocomposite polymer nanofibrous scaffolds and to study the possibility of using it as a potential wound dressing material in the in vivo models.
绝经后伤口护理管理给卫生服务带来了巨大负担，因为与年龄相关的延迟伤口愈合相关的老年人口增加。雌激素替代治疗可以通过其强大的抗炎活性加速急性皮肤伤口的愈合。电纺技术可用于将所需的治疗剂引入纳米纤维基质中。在这里，我们引入了一种用于伤口组织敷料的新材料，其中通过电纺获得了负载β-雌二醇的聚氨酯-葡聚糖复合纳米纤维伤口敷料材料。葡聚糖可以促进慢性伤口中的新生血管形成和皮肤再生。本研究涉及这些纳米纤维的表征以及细胞生长和增殖的分析，以确定组织在这些生物复合聚合物纳米纤维支架上再生的效率，并研究将其用作体内模型中潜在伤口敷料材料的可能性。
