Menchón Silvia A
IFEG-CONICET and FaMAF, Universidad Nacional de Córdoba, Medina Allende s/n, Ciudad Universitaria, 5000, Córdoba, Argentina,
Acta Biotheor. 2015 Jun;63(2):113-27. doi: 10.1007/s10441-015-9248-x. Epub 2015 Mar 8.
Although chemotherapy is one of the most common treatments for cancer, it can be only partially successful. Drug resistance is the main cause of the failure of chemotherapy. In this work, we present a mathematical model to study the impact of both intrinsic (preexisting) and acquired (induced by the drugs) resistances on chemotherapy effectiveness. Our simulations show that intrinsic resistance could be as dangerous as acquired resistance. In particular, our simulations suggest that tumors composed by even a small fraction of intrinsically resistant cells may lead to an unsuccessful therapy very quickly. Our results emphasize the importance of monitoring both intrinsic and acquired resistances during treatment in order to succeed and the importance of doing more experimental and genetic research in order to develop a pretreatment clinical test to avoid intrinsic resistance.
尽管化疗是癌症最常见的治疗方法之一，但它只能部分成功。耐药性是化疗失败的主要原因。在这项工作中，我们提出了一个数学模型来研究内在（预先存在的）和获得性（由药物诱导的）耐药性对化疗效果的影响。我们的模拟表明，内在耐药性可能与获得性耐药性一样危险。特别是，我们的模拟表明，即使是由一小部分内在耐药细胞组成的肿瘤也可能很快导致治疗失败。我们的结果强调了在治疗过程中监测内在和获得性耐药性以取得成功的重要性，以及进行更多实验和基因研究以开发一种预处理临床试验以避免内在耐药性的重要性。
