Luan Yong-Fu, Sun Rong
Zhongguo Zhong Yao Za Zhi. 2014 Oct;39(20):4013-9.
The diarrheal rat model was established by orally administering senna. The preventive experiment was concurrent for 6 days. The treatment experiment modeling had lasted for 12 days. The administration started at the 7th day, and lasted for 6 days. During the experiment, efforts were made in symptom score and weighing. After the experiment, hearts, livers, spleens, kidneys, brains, adrenals and thymuses were collected and weighed, lactic dehydrogenase (LDH) and cardiac troponin-I (cTn-I) in serum were detected. The efficacy of aqueousextracts from Aconiti Lateralis Radix Praeparata in preventing and treating rats with diarrheal and its accompanying toxicity were respectively studied. The result shows that aqueous extracts from Aconiti Lateralis Radix Praeparata could improve syndromes of rats with diarrheal. The 50% effective doses (ED50) of preventive and treatment administrations were 1.420 4 g · kg(-1) and 1.048 9 g · kg(-1), respectively. Aqueous extracts from Aconiti Lateralis Radix Praeparata could decrease the ratio of heart to body weight, and increase serum LDH and cTn-I. It was concluded that aqueous extracts from Aconiti Lateralis Radix Praeparata had a specific preventive and treatment effect on rats with diarrheal caused by senna, but with specific toxicity on heart.
通过口服番泻叶建立腹泻大鼠模型。预防性实验为期6天。治疗性实验建模持续12天。给药从第7天开始，持续6天。实验期间，进行症状评分和称重。实验结束后，收集心脏、肝脏、脾脏、肾脏、大脑、肾上腺和胸腺并称重，检测血清中的乳酸脱氢酶（LDH）和心肌肌钙蛋白I（cTn-I）。分别研究了附子水提取物对腹泻大鼠的防治作用及其伴随的毒性。结果表明，附子水提取物可改善腹泻大鼠的症状。预防性给药和治疗性给药的半数有效剂量（ED50）分别为1.420 4 g·kg⁻¹和1.048 9 g·kg⁻¹。附子水提取物可降低心脏与体重的比值，并升高血清LDH和cTn-I。结论：附子水提取物对番泻叶所致腹泻大鼠有特异性防治作用，但对心脏有特异性毒性。
