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当下的主动脉弓修复:对于大多数主动脉弓病变,开放修复是最佳选择。

Aortic arch repair today: open repair is best for most arch lesions.

作者信息

Coselli J S, Green S Y

机构信息

Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Baylor St. Luke's Medical Center, Houston, TX, USA -

出版信息

J Cardiovasc Surg (Torino). 2015 Aug;56(4):531-46. Epub 2015 Mar 10.

Abstract

The transverse aortic arch is challenging to repair by either evolving open or emerging endovascular approaches. Contemporary experience in aortic arch repair can be difficult to assess because clinical practice varies substantially among centers with regard to temperature targets for hypothermic circulatory arrest, temperature monitoring sites, circulating perfusate temperatures, cerebral perfusion monitoring techniques, perfusion catheter flow rates, cannulation sites, pH management, and protective pharmacologic agents. Repair of the aortic arch has changed substantially over the last decade; these changes appear to have substantially reduced patient risk. In general, contemporary outcomes of open aortic arch repair are good to excellent. When acute aortic dissection is absent, many centers report early mortality rates below 5%; when acute aortic dissection is present, these rates are doubled or tripled. Not unexpectedly, mortality rates for total transverse aortic arch repair with elephant trunk or frozen elephant trunk approaches are greater than those for hemiarch repair (7-17% vs. 3-4%). In contemporary reports of mixed hemiarch and total arch repairs for aortic aneurysm, several authors report early mortality rates and stroke rates below 5%. Surprisingly, mortality rates for reoperation are not unlike those for primary repair and range from 8% to 9%; however, the risk of stroke appears somewhat greater and ranges from 5% to 6%.

摘要

无论是采用不断发展的开放手术方法还是新兴的血管内介入方法,修复主动脉弓横部都具有挑战性。由于各中心在低温循环停搏的温度目标、温度监测部位、循环灌注液温度、脑灌注监测技术、灌注导管流速、插管部位、pH值管理以及保护性药物等临床实践方面存在很大差异,目前主动脉弓修复的经验很难评估。在过去十年中,主动脉弓修复发生了很大变化;这些变化似乎已大幅降低了患者风险。总体而言,当代开放主动脉弓修复的结果良好至极佳。在不存在急性主动脉夹层的情况下,许多中心报告早期死亡率低于5%;存在急性主动脉夹层时,这些比率会翻倍或增至三倍。不出所料,采用象鼻或冰冻象鼻方法进行全主动脉弓横部修复的死亡率高于半弓修复(7%-17%对3%-4%)。在当代关于主动脉瘤半弓和全弓混合修复的报告中,几位作者报告早期死亡率和中风率低于5%。令人惊讶的是,再次手术的死亡率与初次修复的死亡率并无不同,范围在8%至9%之间;然而,中风风险似乎略高,范围在5%至6%之间。

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