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主动脉弓病变高危患者或既往主动脉手术后的腔内修复:中期结果。

Endovascular repair of aortic arch lesions in high-risk patients or after previous aortic surgery: midterm results.

机构信息

Department of Vascular and Thoracic Surgery Arnaud de Villeneuve Hospital, Montpellier, France.

出版信息

J Thorac Cardiovasc Surg. 2010 Jul;140(1):52-8. doi: 10.1016/j.jtcvs.2009.09.022.

Abstract

OBJECTIVE

The aim of this study was to assess the short- and midterm results after endovascular repair of the aortic arch in high-risk patients or after previous aortic surgery.

METHODS

From November 1998 to November 2008, 57 thoracic stent grafts were implanted in 44 patients (sex ratio, 4.5; mean age, 66.5 +/- 16.5 years) for aortic arch repair (zone 0 to 2 according to the arch map proposed by Ishimaru) of 19 degenerative aneurysms, 12 traumatic transections of the aorta, 8 complicated aortic dissections, 4 postcoarctectomy aortic pseudoaneurysms, and 1 penetrating atheromatous ulcer. All patients were considered to be at high surgical risk owing to serious comorbidities (American Society of Anesthesiologists score > or = III [79.5%]) or previous aortic surgery. Endovascular repair was performed in an emergency setting in 27.3% (n = 12) of the patients. Thirty-four underwent a hybrid technique with supra-aortic debranching and simultaneous or staged endovascular stent grafting. Debranching was performed to provide an adequate proximal aortic landing zone, in 28 patients by a cervical approach and in 6 patients by a sternotomy approach.

RESULTS

The technical success rates for aortic zone 0 patients (n = 6), zone 1 patients (n = 4), and zone 2 patients (n = 34) were, respectively, 100%, 100%, and 97%. The 30-day mortality rate was 20.4%. The actuarial survival was 70% over a mean follow-up of 29.9 months. The rate of stroke was 6.8%. Two (4.5%) cases of paraplegia were observed, 1 of which was reversible after cerebrospinal fluid drainage. The rate of endoleak was 15.9% (n = 7): 3 type I, 3 type II, and 1 type III. There were no cases of device migration, but 1 stent-graft collapse occurred 20 days after exclusion of an aortic traumatic transection.

CONCLUSION

Hybrid endovascular aortic arch reconstructions, although some of these adjunctive procedures remain major operations, provide attractive alternatives for treating aortic arch lesions in high-risk patients who would otherwise be unsuitable for open repair, with acceptable primary results and encouraging midterm efficacy to prevent rupture.

摘要

目的

本研究旨在评估高危患者或既往主动脉手术后行主动脉弓腔内修复的短期和中期结果。

方法

1998 年 11 月至 2008 年 11 月,44 例患者(性别比 4.5;平均年龄 66.5 ± 16.5 岁)接受了 57 个胸主动脉支架移植物植入术,用于修复主动脉弓(根据 Ishimaru 提出的弓图谱分为 0 区至 2 区),其中包括 19 例退行性动脉瘤、12 例创伤性主动脉横断、8 例复杂主动脉夹层、4 例主动脉缩窄后假性动脉瘤和 1 例穿透性粥样硬化性溃疡。所有患者均因严重合并症(美国麻醉医师协会评分>或= III 级[79.5%])或既往主动脉手术而被认为存在手术高风险。27.3%(n=12)的患者在紧急情况下进行了腔内修复。34 例行杂交技术,包括主动脉弓分支和同期或分期腔内支架移植物置入。为了提供足够的近端主动脉锚定区,28 例患者采用颈侧入路,6 例患者采用胸骨切开入路进行去分支。

结果

主动脉 0 区患者(n=6)、1 区患者(n=4)和 2 区患者(n=34)的技术成功率分别为 100%、100%和 97%。30 天死亡率为 20.4%。平均随访 29.9 个月后,累计生存率为 70%。卒中发生率为 6.8%。观察到 2 例(4.5%)截瘫,其中 1 例经脑脊液引流后可逆转。内漏发生率为 15.9%(n=7):3 型 I、3 型 II 和 1 型 III。无器械移位病例,但 1 例支架移植物塌陷发生在排除创伤性主动脉横断后 20 天。

结论

虽然这些辅助手术中的一些仍然是主要手术,但杂交腔内主动脉弓重建术为高危患者提供了有吸引力的替代治疗选择,这些患者如果进行开放修复则不合适,其初始结果可接受,中期疗效令人鼓舞,可预防破裂。

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