Department of Physiology, The NHLBI Proteomics Center at UCLA, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Expert Rev Proteomics. 2015 Apr;12(2):133-46. doi: 10.1586/14789450.2015.1024227. Epub 2015 Mar 9.
Mitochondrial proteins alter in their composition and quantity drastically through time and space in correspondence to changing energy demands and cellular signaling events. The integrity and permutations of this dynamism are increasingly recognized to impact the functions of the cardiac proteome in health and disease. This article provides an overview on recent advances in defining the spatial and temporal dynamics of mitochondrial proteins in the heart. Proteomics techniques to characterize dynamics on a proteome scale are reviewed and the physiological consequences of altered mitochondrial protein dynamics are discussed. Lastly, we offer our perspectives on the unmet challenges in translating mitochondrial dynamics markers into the clinic.
线粒体蛋白在时间和空间上的组成和数量会发生剧烈变化，以适应不断变化的能量需求和细胞信号事件。这种动态的完整性和变化越来越被认为会影响心脏蛋白质组在健康和疾病中的功能。本文概述了定义心脏中线粒体蛋白时空动态的最新进展。综述了用于在蛋白质组范围内描述动力学的蛋白质组学技术，并讨论了线粒体蛋白动力学改变的生理后果。最后，我们对将线粒体动力学标志物转化为临床应用所面临的挑战提出了看法。
